Abstract In polymer-based aqueous biphasic systems (ABSs), the understanding the role of different types of polymers in phase separation is important in the selection of a suitable ABS used for separation of biomaterials. For this purpose, in this work, a systematic investigation of ternary aqueous solutions containing one deep eutectic solvent (NADES) obtained from mixtures of choline chloride as HBA and D-sucrose as HBD, and different water soluble polymers polyethylene glycol 400 (PEG400), polypropylene glycol 400 (PPG400), and polyethylene glycol dimethyl ether 250 (PEGDME250) at a molar ratio of 1:1 was made by the volumetric, ultrasonic, and vapor-liquid equilibria (VLE) studies at T = 298.15 K. The obtained water iso-activity lines showed that the system containing PPG400 and NADES has negative deviation from the semi-ideal solution and therefore solute-solvent interactions are unfavorable suggesting the occurrence of phase separation in this system. But in the case of PEG400 and PEGDME250 these deviations are positive and there are favorable interactions between the polymers and NADES which means that phase separation in these systems is unlikely. The obtained values from the density and acoustic studies were used for calculating the limiting values for apparent molar volume V φ 0 , apparent molar isentropic compressibility k φ 0 , the transfer molar volume Δ tr V φ 0 , and also isentropic compressibility Δ tr k φ 0 of polymers from water to aqueous NADES solutions. These results are consistent with the results of water activity measurements in regard to the solute-solvent interactions and phase separation in the studied ternary systems.

中文翻译：

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通过气液平衡、体积和声学研究评估含有氯化胆碱/D-蔗糖天然低共熔溶剂的聚合物水溶液的溶质-溶剂相互作用和相分离

摘要 在聚合物基水性双相体系 (ABS) 中，了解不同类型聚合物在相分离中的作用对于选择合适的 ABS 用于分离生物材料非常重要。为此，在这项工作中，系统研究了含有一种深共熔溶剂 (NADES) 的三元水溶液，这些溶液是从氯化胆碱作为 HBA 和 D-蔗糖作为 HBD 的混合物，以及不同的水溶性聚合物聚乙二醇 400 (PEG400) 的混合物中获得的，聚乙二醇 400 (PPG400) 和聚乙二醇二甲醚 250 (PEGDME250) 以 1:1 的摩尔比通过体积、超声和汽液平衡 (VLE) 研究在 T = 298.15 K 下制备。得到的水等活度线表明，含有 PPG400 和 NADES 的体系与半理想溶液有负偏差，因此溶质 - 溶剂相互作用是不利的，表明该体系中发生了相分离。但是在 PEG400 和 PEGDME250 的情况下，这些偏差是正的，并且聚合物和 NADES 之间存在有利的相互作用，这意味着这些系统中的相分离是不可能的。从密度和声学研究中获得的值用于计算表观摩尔体积 V φ 0 、表观摩尔等熵压缩率 k φ 0 、转移摩尔体积 Δ tr V φ 0 以及等熵压缩率 Δ tr k φ 的极限值0 聚合物从水到 NADES 水溶液。