Cyclooxygenase-2 (COX-2) is an inducible enzyme that plays a key role in the inflammatory cascade through the generation of prostaglandins. Recent studies have found that COX-2 is closely related to the occurrence and development of tumors, angiogenesis and metastasis of tumors. Overexpressed COX-2 has become a predictive biomarker for progression of pre-malignant towards cancer in some tissues, which makes the detection of COX-2 of great value and clinical significance. This review highlights COX-2-specific fluorescent probes based on small organic molecules, including their design strategies and applications in the detection and imaging of COX-2 in vitro and in vivo. The progress suggests that fluorescence detection and imaging of COX-2 is a vital and rapidly technology for early diagnosis of tumors.

中文翻译：

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COX-2特异性荧光探针的设计和构建。

环氧合酶2（COX-2）是一种可诱导的酶，通过产生前列腺素在炎症级联反应中起关键作用。最近的研究发现，COX-2与肿瘤的发生和发展，肿瘤的血管生成和转移密切相关。过表达的COX-2已成为某些组织中恶性肿瘤向癌症进展的预测生物标志物，这使得COX-2的检测具有重要的价值和临床意义。这篇综述重点介绍了基于有机小分子的COX-2特异性荧光探针，包括其设计策略以及在体外和体内COX-2的检测和成像中的应用。该进展表明，COX-2的荧光检测和成像是早期诊断肿瘤的一项至关重要的技术。