Abstract Solvothermal reaction of Zn(NO3) · 6H2O with the tripodal ligand 1,3,5-tris(4-carboxyphenyl)benzene (H3BTB) afforded a highly porous metal-organic framework (MOF) {[Zn3(BTB)2(H2O)2] · 7DMF}n (1). The resulting activated 1a exhibits BET surface areas of 1021 m2 g−1 with a pore size distribution around 11.8 Å, which was further applied in the cyanosilylation of aldehydes under solvent-free conditions. The experimental results show that, using 1a as the catalyst, both aliphatic and aromatic aldehydes were efficiently transformed to cyanohydrin trimethylsilyl ether. Meanwhile, significant size selectivity and electronic effects have also been observed. Then, we evaluated the anticancer activity of the synthesized compound 1a on six different kinds of cancer cell lines, including HeLa, CHO, HepG2, MG-63, MAD-MB-435, and BEAS-2B. CCK-8 results indicated 1a showed excellent inhibitory effect on cell proliferation, especially on the MG-63 human osteogenic sarcoma cells. Next, a transwell assay was performed to detect the migration and invasion activity of MG-63 cells after compound 1a treatment. Graphical Abstract

中文翻译：

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含有配位不饱和Zn(II)中心的多孔金属-有机骨架催化醛的氰硅烷化及其在人成骨肉瘤中的抗癌活性

摘要 Zn(NO3)·6H2O 与三足配体 1,3,5-三(4-羧基苯基)苯 (H3BTB) 的溶剂热反应提供了高度多孔的金属有机骨架 (MOF) {[Zn3(BTB)2(H2O) )2] · 7DMF}n (1)。所得活化的 1a 的 BET 表面积为 1021 m2 g-1，孔径分布约为 11.8 Å，进一步应用于无溶剂条件下醛的氰基硅烷化。实验结果表明，以1a为催化剂，脂肪醛和芳香醛均有效地转化为氰醇三甲基甲硅烷基醚。同时，还观察到显着的尺寸选择性和电子效应。然后，我们评估了合成的化合物 1a 对六种不同癌细胞系的抗癌活性，包括 HeLa、CHO、HepG2、MG-63、MAD-MB-435 和 BEAS-2B。CCK-8结果表明1a对细胞增殖有很好的抑制作用，尤其是对MG-63人成骨肉瘤细胞。接下来，进行transwell试验以检测化合物1a处理后MG-63细胞的迁移和侵袭活性。图形概要