A comparative in silico analysis of Rab5 proteins from pathogenic species to find its role in the pathogenesis.,Journal of Molecular Recognition

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A comparative in silico analysis of Rab5 proteins from pathogenic species to find its role in the pathogenesis.
Journal of Molecular Recognition ( IF 2.3 ) Pub Date : 2019-08-20 , DOI: 10.1002/jmr.2808
Vijay Kumar Srivastava ₁ , Sanket Kaushik ₁ , Anupam Jyoti ₁

Affiliation

The enteric protozoan parasite, Entamoeba histolytica (Eh), is the causative agent of amoebic dysentery and liver abscess in humans. It infects around 50 million people worldwide, which is a third general cause of death from parasitic diseases after malaria and schistosomiasis. The other prevalent form of the disease is Visceral leishmaniasis caused by Leishmania donovani which is a human blood parasite. On the other hand, the Toxoplasma gondii is an obligate intracellular protozoan parasite; it causes serious opportunistic infections in HIV-positive persons. The biological processes in all living organisms are mostly mediated by the proteins, and recognizing new target proteins and finding their function in pathogenesis will help in choosing better diagnostic markers. In eukaryotes, Rab protein plays a major role in pathogenesis. Rabs represent the largest branch in the Ras superfamily of GTPases. Among them, the Rab5 is important in the endocytosis and thus involved in pathogenesis. In this paper, we discussed the physiochemical profiling, modelling, and docking of the Rab5 protein from pathogenic species that is Entamoeba histolytica, Leishmania donovani, and Toxoplasma gondii. The modeled structures from this study and the key residues identified would give a better understanding of the three-dimensional structure and functional insights into these proteins and help in developing new drug targets.

中文翻译：

对来自病原体的Rab5蛋白进行计算机比较分析，以发现其在发病机理中的作用。

肠原生动物寄生虫，组织变形虫（Etamoeba histolytica，Eh）是人类阿米巴痢疾和肝脓肿的病原体。它感染了全世界约五千万人，这是继疟疾和血吸虫病之后由寄生虫病造成的第三大死亡原因。该疾病的另一流行形式是由利什曼原虫多诺万尼引起的内脏利什曼病，其是人的血液寄生虫。另一方面，弓形虫是专性的细胞内原生动物寄生虫。它会在HIV阳性患者中造成严重的机会性感染。所有活生物体中的生物过程主要由蛋白质介导，识别新的目标蛋白质并发现其在发病机理中的作用将有助于选择更好的诊断标记。在真核生物中，Rab蛋白在发病机理中起主要作用。Rabs代表了GTPases的Ras家族中最大的分支。其中，Rab5在胞吞作用中很重要，因此参与了发病机理。在本文中，我们讨论了来自致病性物种西班牙变形杆菌，利什曼原虫和弓形虫的Rab5蛋白的理化分析，建模和对接。这项研究的建模结构和确定的关键残基将更好地理解这些蛋白质的三维结构和功能性见解，并有助于开发新的药物靶标。Rab5蛋白与致病性变形杆菌，利什曼原虫和弓形虫的致病物种对接。这项研究的建模结构和确定的关键残基将更好地理解这些蛋白质的三维结构和功能性见解，并有助于开发新的药物靶标。Rab5蛋白与致病性变形杆菌，利什曼原虫和弓形虫的致病物种对接。这项研究的建模结构和确定的关键残基将使人们更好地了解这些蛋白质的三维结构和功能见解，并有助于开发新的药物靶标。

更新日期：2019-08-20

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