Recently in Canada and some states of the United States, marijuana (cannabis) has become fully legalized and regulated, for both medical and recreational purposes. This fact is going to make cannabis products such as edibles even more popular than ever before. Therefore, it is assumed that there will be a high demand for analytical methods, which are accurate and sensitive enough to be used in different forensic and pharmaceutical cannabis-related applications. Cannabis derivatives have an extreme range and number of constituents with possible interactions with one another. Thus, this characteristic leads to their vast and highly complex chemistry, which requires robust analytical tools to be able to precisely and accurately quantify and qualify them. We developed and validated an analytical method using desorption electrospray ionization (DESI)-mass spectrometry (MS) to accurately detect, characterize, and quantify cannabinoids and also offer an easy, cost-effective, and reliable technique, which can be performed in a short time for infused edibles in complex matrices such as chocolate. We evaluated a quantitative analysis of tetrahydrocannabinol (THC) in cannabis-infused chocolate with thin-layer chromatography (TLC)-DESI-MS and QuEChERS extraction method. Both techniques of TLC and QuEChERS are cost-effective and can be run in short time.

中文翻译：

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QuEChERS薄层色谱-脱附电喷雾电离质谱法分析注入大麻的巧克力中的四氢大麻酚衍生物。

最近，在加拿大和美国的某些州，出于医疗和娱乐目的，大麻（大麻）已经完全合法化并受到管制。这一事实将使大麻食品（例如食用食品）比以往任何时候都更加受欢迎。因此，假设对分析方法的需求很高，这些分析方法足够准确和灵敏，可用于不同的法医和制药大麻相关应用。大麻衍生物具有极高的范围和数量的成分，并且可能彼此相互作用。因此，此特征导致了它们庞大而高度复杂的化学反应，这需要强大的分析工具才能准确准确地对其进行定量和鉴定。我们开发并验证了使用解吸电喷雾电离（DESI）-质谱（MS）来准确检测，表征和定量大麻素的分析方法，还提供了一种简便，经济高效且可靠的技术，可在短时间内完成在复杂的基质（如巧克力）中注入可食用食物的时间。我们使用薄层色谱（TLC）-DESI-MS和QuEChERS提取方法评估了注入大麻的巧克力中四氢大麻酚（THC）的定量分析。TLC和QuEChERS两种技术都具有成本效益，并且可以在短时间内运行。我们使用薄层色谱（TLC）-DESI-MS和QuEChERS提取方法评估了注入大麻的巧克力中四氢大麻酚（THC）的定量分析。TLC和QuEChERS两种技术都具有成本效益，并且可以在短时间内运行。我们使用薄层色谱（TLC）-DESI-MS和QuEChERS提取方法评估了注入大麻的巧克力中四氢大麻酚（THC）的定量分析。TLC和QuEChERS两种技术都具有成本效益，并且可以在短时间内运行。