This article is written for the 2020 tool issue of Protein Science. It briefly introduces the widely used antimicrobial peptide database, initially online in 2003. After a description of the main features of each database version and some recent additions, the focus is on the peptide design parameters for each of the four unified classes of natural antimicrobial peptides (AMPs). The amino acid signature in AMPs varies substantially, leading to a variety of structures for functional and mechanistic diversity. Also, Nature is a master of combinatorial chemistry by deploying different amino acids onto the same structural scaffold to tune peptide functions. In addition, the single-domain AMPs may be posttranslationally modified, self-assembled, or combined with other AMPs for function. Elucidation of the design principles of natural AMPs will facilitate future development of novel molecules for various applications.

中文翻译：

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抗菌肽数据库提供了一个解码天然抗菌肽设计原理的平台。


本文是为《Protein Science》2020 年工具期撰写的。它简要介绍了广泛使用的抗菌肽数据库，该数据库于 2003 年首次上线。在描述了每个数据库版本的主要特征和最近添加的一些内容之后，重点是四个统一类别的天然抗菌肽中每一类的肽设计参数（AMP）。 AMP 中的氨基酸特征差异很大，从而导致功能和机制多样性的多种结构。此外，《Nature》是组合化学的大师，通过将不同的氨基酸部署到相同的结构支架上来调整肽的功能。此外，单域 AMP 可以进行翻译后修饰、自组装或与其他 AMP 组合以实现功能。阐明天然 AMP 的设计原理将有助于未来开发用于各种应用的新型分子。