Bovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA-binding domain of the dominant transcription regulator from the bovine papillomavirus strain 1 is described in the space group P31 21. We found two protein functional dimers packed in the asymmetric unit. This new protein arrangement inside the crystal led to the reduction of the mobility of a previously unobserved loop directly involved in the protein-DNA interaction, which was then modeled for the first time.

中文翻译：

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牛乳头瘤病毒-1的扩展E2 DNA结合域的结构。

牛乳头瘤病毒蛋白作为人类乳头瘤病毒的原型已被广泛研究。在这里，在空间群P31 21中描述了来自牛乳头瘤病毒株1的显性转录调节子的扩展E2 DNA结合结构域的晶体结构。我们发现在不对称单元中有两个蛋白质功能性二聚体。晶体内部这种新的蛋白质排列导致直接参与蛋白质-DNA相互作用的先前未观察到的环的迁移率降低，然后首次对其进行了建模。