BACKGROUND The UF-1000i has been widely used in screening urinary sediments. However, the interference factor of the UF-1000i in the screening urinary sediments of pregnant women has not been reported. The aim of the study was to demonstrate that epithelial cells (ECs) cause a high false positive rate of white blood cells (WBCs) by the UF-1000i in pregnant women. METHODS Urine samples were collected from 207 pregnant women. All samples were measured by the UF-1000i and a microscopic method. RESULTS The areas under the curve (AUC) for WBC and EC counts were 0.837 (95% CI, 0.773-0.901) and 0.844 (95% CI, 0.785-0.903), respectively. The positive rates of the WBC and EC were 73.43% and 37.20%, respectively, by the UF-1000i, and they were 19.32% and 72.95% by the microscopic method. The positive predictive value, negative predictive value, false positive rates, and false negative rates by the UF-1000i were for WBC 25.66%, 98.18%, 74.34%, and 1.82%, respectively, and for EC they were 96.1%, 40.77%, 3.9%, and 59.23%, respectively. The coefficient of correlation R value was 0.503 (P < 0.01) between WBC by UF-1000i and EC by the microscopic method in WBC false positive samples. CONCLUSIONS EC could be an interference factor for the UF-1000i in screening urinary WBC of pregnant women, and the high false positive rate for WBC may be caused by ECs being misclassified as WBCs by the UF-1000i. © 2018 The Authors. Cytometry Part B: Clinical Cytometry published by Wiley Periodicals, Inc. on behalf of International Clinical Cytometry Society.

中文翻译：

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孕妇尿样中白细胞假阳性率高可能是由于sysmex UF-1000i尿流式细胞仪将上皮细胞分类错误。

背景技术UF-1000i已被广泛用于筛查尿沉渣。但是，尚未报道UF-1000i在筛查孕妇尿沉渣中的干扰因素。该研究的目的是证明UF-1000i在孕妇中引起上皮细胞（EC）引起白细胞（WBC）的高假阳性率。方法收集207例孕妇的尿液样本。通过UF-1000i和显微镜方法测量所有样品。结果WBC和EC计数的曲线下面积（AUC）分别为0.837（95％CI，0.773-0.901）和0.844（95％CI，0.785-0.903）。UF-1000i的WBC和EC的阳性率分别为73.43％和37.20％，而显微法分别为19.32％和72.95％。正预测值，负预测值，UF-1000i的假阳性率和假阴性率分别为WBC的25.66％，98.18％，74.34％和1.82％，而EC的分别为96.1％，40.77％，3.9％和59.23％。 。在WBC假阳性样品中，用UF-1000i检测的WBC和用显微镜法观察到的EC之间的相关系数R值为0.503（P <0.01）。结论EC可能是UF-1000i筛查孕妇尿WBC的干扰因素，WBC假阳性率高可能是由于UF-1000i将EC误分类为WBC所致。©2018作者。细胞计数法B部分：Wiley Periodicals，Inc.代表国际临床细胞计数学会出版的临床细胞计数法。分别为3.9％和59.23％。在WBC假阳性样品中，用UF-1000i检测的WBC和用显微镜法观察到的EC之间的相关系数R值为0.503（P <0.01）。结论EC可能是UF-1000i筛查孕妇尿WBC的干扰因素，WBC假阳性率高可能是由于UF-1000i将EC误分类为WBC所致。©2018作者。细胞计数法B部分：Wiley Periodicals，Inc.代表国际临床细胞计数学会出版的临床细胞计数法。分别为3.9％和59.23％。在WBC假阳性样品中，用UF-1000i检测的WBC和用显微镜法观察到的EC之间的相关系数R值为0.503（P <0.01）。结论EC可能是UF-1000i筛查孕妇尿WBC的干扰因素，WBC假阳性率高可能是由于UF-1000i将EC误分类为WBC所致。©2018作者。细胞计数法B部分：Wiley Periodicals，Inc.代表国际临床细胞计数学会出版的临床细胞计数法。WBC的假阳性率高可能是由于UF-1000i将EC误分类为WBC所致。©2018作者。细胞计数法B部分：Wiley Periodicals，Inc.代表国际临床细胞计数学会出版的临床细胞计数法。WBC的假阳性率高可能是由于UF-1000i将EC误分类为WBC所致。©2018作者。细胞计数法B部分：Wiley Periodicals，Inc.代表国际临床细胞计数学会出版的临床细胞计数法。