Synthesis, spectral characterization, and biological evaluation of imidazole‐substituted pyridine‐2‐amine and benzo‐substituted imidazole‐2‐amine,Journal of the Chinese Chemical Society

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Synthesis, spectral characterization, and biological evaluation of imidazole‐substituted pyridine‐2‐amine and benzo‐substituted imidazole‐2‐amine
Journal of the Chinese Chemical Society ( IF 1.6 ) Pub Date : 2019-05-29 , DOI: 10.1002/jccs.201800461
Shaik Mahaboob Basha ₁ , Mavallur Varalakshmi ₂ , Shaik Thaslim Basha ₃ , Chintha Venkataramaiah ₄ , Suban Syed Shafi ₁ , Chamarthi Naga Raju ₃ , Wudayagiri Rajendra ₄

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A series of new imidazole‐substituted pyridine‐2‐amine and benzo‐substituted imidazol‐2‐amine 3–12 were synthesized by treating various amines 1(a–d) with alkyl/aryl isothiocyanate 2(a‐c) at 60–90°C in isopropyl alcohol without using any catalyst with high yields. The structures of all the newly synthesized compounds were characterized using IR, NMR (¹H, ¹³C), mass, and elemental analyses. All the newly synthesized compounds were screened for their in vitro antioxidant and antimicrobial activities to understand their biological potency. All the title compounds exhibited good antioxidant and antimicrobial activities in vitro when compared to the standard drugs.

中文翻译：

咪唑取代的吡啶-2-胺和苯并取代的咪唑-2-胺的合成，光谱表征和生物学评估

一系列新的咪唑取代的吡啶-2-胺和苯并取代的咪唑-2-胺3 – 12通过在60–60 ℃下用烷基/芳基异硫氰酸酯2（ ac ）处理各种胺1（a – d）合成。在异丙醇中在90°C下使用，不使用任何催化剂，高收率。所有新合成的化合物的结构均采用IR，NMR（¹ H，¹³C），质量和元素分析。筛选所有新合成的化合物的体外抗氧化剂和抗菌活性，以了解其生物学潜能。与标准药物相比，所有标题化合物在体外均表现出良好的抗氧化和抗菌活性。

更新日期：2019-12-11

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