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The leading established metal-based drugs: a revisitation of their relevant physico-chemical data
Biometals ( IF 4.1 ) Pub Date : 2019-08-31 , DOI: 10.1007/s10534-019-00210-7
Damiano Cirri , Maria Giulia Fabbrini , Alessandro Pratesi , Lorenzo Ciofi , Lara Massai , Tiziano Marzo , Luigi Messori

The study of metal-based drugs represents an important branch of modern bioinorganic chemistry. The growing importance of this field is linked to the large success in medicine of a few metal based drugs, either in clinical use or still experimental. Moreover, these metal-based drugs are frequently used as reference compounds to assess comparatively the behavior of newly synthesized metallodrugs. For the convenience of researchers working in this area we report here a compilation of the relevant analytical and spectroscopic data of ten representative metallodrugs based on Platinum, Ruthenium, Gold and Mercury. The selected compounds, namely Cisplatin, Oxaliplatin, Carboplatin, Auranofin, Sodium Aurothiomalate, NAMI-A, KP1019, Thimerosal, Merbromin and Phenylmercury Acetate, were chosen owing to their importance in the field. We believe that this compilation may turn very helpful to researchers as these data are difficult to find and generally scattered over a large number of (old) publications.



中文翻译:

领先的基于金属的药物:其相关理化数据的回顾

金属基药物的研究代表了现代生物无机化学的重要分支。该领域的日益增长的重要性与几种基于金属的药物在医学上的巨大成功有关,无论是在临床上还是在实验中。此外,这些基于金属的药物经常用作参考化合物,以比较地评估新合成的金属药物的行为。为了方便从事这一领域的研究人员,我们在此报告了基于铂,钌,金和汞的十种代表性金属药物的相关分析和光谱数据的汇总。由于它们在该领域中的重要性,因此选择了所选择的化合物,即顺铂,奥沙利铂,卡铂,金诺芬,金硫代苹果酸钠,NAMI-A,KP1019,硫柳汞,Merbromin和苯基乙酸汞。

更新日期:2019-08-31
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