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Novel contrast media based on the liquid metal gallium for in vivo digestive tract radiography: a feasibility study
Biometals ( IF 3.5 ) Pub Date : 2019-09-25 , DOI: 10.1007/s10534-019-00212-5
Huan Liu , Yang Yu , Wei Wang , Ying Liu , Yonghui An , Qian Wang , Jing Liu

The barium sulfate has been playing an important role as the contrast medium in gastrointestinal radiography and disease diagnosis. However, its application has been gradually reduced due to the limitation of its imaging effect and the progress of other imaging techniques. Here, the liquid metal gallium was proposed as an improved contrast agent, which was applied in the in vivo digestive tract radiography of the mice for the first time. Under the CT scanning, the gallium produced excellent contrast effect intuitively. According to the records of discharge time, the tissue sections of organs, the survival state and body weight, the liquid metal was proven to be capable and safe for gastrointestinal radiography. Further, the mixture of the gallium and the barium sulfate has been tested, which showed better performance in both contrast and detail. Therefore, with the characteristics of better imaging contrast effect and acceptable safety, the gallium and its mixture with the barium sulfate might be useful as potential candidates for digestive tract contrast agent in animal experiments, even possibly as alternative contrast agents for clinical use.



中文翻译:

基于液态金属镓的新型造影剂在体内消化道放射照相中的可行性研究

硫酸钡作为胃肠道造影和疾病诊断中的造影剂一直发挥着重要作用。然而,由于其成像效果的限制以及其他成像技术的进步,其应用已逐渐减少。在此,提出了液态金属镓作为改进的造影剂,其首次在小鼠的体内消化道射线照相中应用。在CT扫描下,镓直观地产生了出色的对比度效果。根据放电时间,器官的组织切片,存活状态和体重的记录,液态金属被证明能够并安全地进行胃肠X线照相。此外,已经测试了镓和硫酸钡的混合物,其在对比度和细节上均表现出更好的性能。

更新日期:2019-09-25
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