Enzymatic self-sufficient hydride transfer processes.,Chemical Society Reviews

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Enzymatic self-sufficient hydride transfer processes.
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2019-11-01 , DOI: 10.1039/c8cs00903a
Erika Tassano ₁ , Mélanie Hall ₁

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A number of self-sufficient hydride transfer processes have been reported in biocatalysis, with a common feature being the dependence on nicotinamide as a cofactor. This cofactor is provided in catalytic amounts and serves as a hydride shuttle to connect two or more enzymatic redox events, usually ensuring overall redox neutrality. Creative systems were designed to produce synthetic sequences characterized by high hydride economy, typically going in hand with excellent atom economy. Several redox enzymes have been successfully combined in one-pot one-step to allow functionalization of a large variety of molecules while preventing by-product formation. This review analyzes and classifies the various strategies, with a strong focus on efficiency, which is evaluated here in terms of the hydride economy and measured by the turnover number of the nicotinamide cofactor(s). The review ends with a critical evaluation of the reported systems and highlights areas where further improvements might be desirable.

中文翻译：

酶促自给自足的氢化物转移过程。

生物催化中已经报道了许多自给自足的氢化物转移过程，其共同特征是依赖烟酰胺作为辅助因子。该辅因子以催化量提供，并用作连接两个或多个酶促氧化还原事件的氢化物梭子，通常确保整体氧化还原中性。创造性系统旨在产生具有高氢化物经济性的合成序列，通常与出色的原子经济性相结合。几种氧化还原酶已成功地在一锅一步中组合，以实现多种分子的功能化，同时防止副产物的形成。这篇综述对各种策略进行了分析和分类，重点关注效率，此处根据氢化物经济性进行评估，并通过烟酰胺辅助因子的周转数进行测量。审查以对所报告的系统进行严格评估结束，并强调可能需要进一步改进的领域。

更新日期：2019-11-01

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