Bacterial RNA degradosomes are multienzyme molecular machines that act as hubs for post-transcriptional regulation of gene expression. The ribonuclease activities of these complexes require tight regulation, as they are usually essential for cell survival while potentially destructive. Recent studies have unveiled a wide variety of regulatory mechanisms including autoregulation, post-translational modifications, and protein compartmentalization. Recently, the subcellular organization of bacterial RNA degradosomes was found to present similarities with eukaryotic messenger ribonucleoprotein (mRNP) granules, membraneless compartments that are also involved in mRNA and protein storage and/or mRNA degradation. In this review, we present the current knowledge on the composition and targets of RNA degradosomes, the most recent developments regarding the regulation of these machineries, and their similarities with the eukaryotic mRNP granules.

中文翻译：

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细菌RNA降解体：在严格控制下的分子机器。

细菌RNA降解体是多酶分子机器，可充当基因表达的转录后调控的枢纽。这些复合物的核糖核酸酶活性需要严格调节，因为它们通常对细胞存活至关重要，同时具有潜在的破坏性。最近的研究揭示了各种各样的调节机制，包括自动调节，翻译后修饰和蛋白质区室化。最近，细菌RNA降解体的亚细胞结构被发现与真核生物信使核糖核蛋白（mRNP）颗粒，无膜隔室相似，它们也参与mRNA和蛋白质的储存和/或mRNA降解。在这篇评论中，我们介绍了有关RNA降解体的组成和目标的最新知识，