Ticks are hematophagous arachnids that parasitize mammals and other hosts, feeding on their blood. Ticks secrete numerous salivary factors that enhance host blood flow or suppress the host inflammatory response. The recruitment of leukocytes, a hallmark of inflammation, is regulated by chemokines, which activate chemokine receptors on the leukocytes. Ticks target this process by secreting glycoproteins called Evasins, which bind to chemokines and prevent leukocyte recruitment. This review describes the recent discovery of numerous Evasins produced by ticks, their classification into two structural and functional classes, and the efficacy of Evasins in animal models of inflammatory diseases. The review also proposes a standard nomenclature system for Evasins and discusses the potential of repurposing or engineering Evasins as therapeutic anti-inflammatory agents.

中文翻译：

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Evasins：抑制哺乳动物趋化因子的蜱唾液蛋白。

蜱是吸血的蛛形纲动物，寄生于哺乳动物和其他宿主，以它们的血液为食。蜱分泌大量唾液因子，可增强宿主血流或抑制宿主炎症反应。白细胞的募集是炎症的标志，受趋化因子调节，趋化因子激活白细胞上的趋化因子受体。蜱通过分泌称为 Evasins 的糖蛋白来靶向这一过程，这种糖蛋白与趋化因子结合并阻止白细胞募集。这篇综述描述了最近发现的由蜱产生的大量 Evasin，它们分为结构和功能两类，以及 Evasin 在炎症性疾病动物模型中的功效。