Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity.,Drug Discovery Today

当前位置： X-MOL 学术 › Drug. Discov. Today › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity.
Drug Discovery Today ( IF 6.5 ) Pub Date : 2019-11-01 , DOI: 10.1016/j.drudis.2019.09.022
Shraddha Thakkar ₁ , Ting Li ₁ , Zhichao Liu ₁ , Leihong Wu ₁ , Ruth Roberts ₂ , Weida Tong ₁

Affiliation

Drug-induced liver injury (DILI) is of significant concern to drug development and regulatory review because of the limited success with existing preclinical models. For developing alternative methods, a large drug list is needed with known DILI severity and toxicity. We augmented the DILIrank data set [annotated using US Food and Drug Administration (FDA) drug labeling)] with four literature datasets (N >350 drugs) to generate the largest drug list with DILI classification, called DILIst (DILI severity and toxicity). DILIst comprises 1279 drugs, of which 768 were DILI positives (increase of 65% from DILIrank), whereas 511 were DILI negatives (increase of 65%). The investigation of DILI positive-negative distribution across various therapeutic categories revealed the most and least frequent DILI categories. Thus, we consider DILIst to be an invaluable resource for the community to improve DILI research.

中文翻译：

药物性肝损伤的严重性和毒性（DILIst）：按人肝毒性对1279种药物进行二分类。

药物诱发的肝损伤（DILI）与药物开发和监管审查密切相关，因为现有的临床前模型取得的成功有限。为了开发替代方法，需要具有已知DILI严重性和毒性的大量药物清单。我们使用四个文献数据集（N> 350种药物）扩充了DILIrank数据集（使用美国食品和药物管理局（FDA）药物标注），以生成最大的DILI分类药物列表，称为DILIst（DILI严重性和毒性）。DILIst包含1279种药物，其中768种为DILI阳性（比DILIrank增长65％），而511种为DILI阴性（增长65％）。对各种治疗类别的DILI阳性-阴性分布的调查显示，最频繁和最不频繁的DILI类别。因此，

更新日期：2019-11-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11