Pharmacological and toxicological aspects of carbon nanotubes (CNTs) to vascular system: A review.,Toxicology and Applied Pharmacology

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Pharmacological and toxicological aspects of carbon nanotubes (CNTs) to vascular system: A review.
Toxicology and Applied Pharmacology ( IF 3.3 ) Pub Date : 2019-11-01 , DOI: 10.1016/j.taap.2019.114801
Yi Cao ₁ , Yingmei Luo ₁

Affiliation

Carbon nanotubes (CNTs) are novel carbon based nanomaterials (NMs) that could be used in many areas ranging from electronics to biotechnology. The present review summarized pharmacological and toxicological aspects of CNTs to vascular systems, because the vascular systems are important targets for CNTs during manufacturing process, daily contact and biomedical uses. Functionalized CNTs could be used as novel nanoplateforms to regulate angiogenesis for cancer therapy, as well as nanocarriers to cross blood brain barrier (BBB), one of the major obstacles to prevent the entering of therapeutic substances into brains. However, it has also been shown that inhalational or intravenous contact with CNTs might induce adverse vascular effects, such as progression of atherosclerotic plaque, vasomotor dysfunction, and changes of blood pressure and/or heart rate in laboratory animals, although currently there are only limited reports obtained from CNT-exposed human beings and the results are inconclusive. The mechanisms associated with the vascular toxicity of CNTs remain poorly understood, and it appears that multiple signaling pathways are likely to be involved. The toxicity of CNTs to vascular systems might be reduced by controlling the physicochemical properties of CNTs, particularly lengths, diameters and surface chemistry. At present, the beneficial and adverse effects of CNTs to vascular systems are still largely unknown and require further extensive studies.

中文翻译：

碳纳米管（CNTs）对血管系统的药理学和毒理学方面：综述。

碳纳米管（CNTs）是新型的基于碳的纳米材料（NMs），可用于从电子到生物技术的许多领域。本综述总结了碳纳米管对血管系统的药理和毒理学方面，因为在制造过程，日常接触和生物医学用途中，血管系统是碳纳米管的重要目标。功能化的CNT可以用作调节癌症治疗血管新生的新型纳米平台，也可以用作跨血脑屏障（BBB）的纳米载体，而血脑屏障是防止治疗性物质进入大脑的主要障碍之一。但是，也已经表明，与CNT吸入或静脉接触可能会引起不利的血管作用，例如动脉粥样硬化斑块的进展，血管舒缩功能障碍，以及实验动物的血压和/或心率的变化，尽管目前只有很少的关于CNT暴露的人的报道，而且结果尚无定论。与CNTs的血管毒性相关的机制仍知之甚少，而且似乎可能涉及多个信号通路。碳纳米管对血管系统的毒性可通过控制碳纳米管的理化特性，特别是长度，直径和表面化学性质来降低。目前，碳纳米管对血管系统的有利和不利影响仍是未知之数，需要进一步的广泛研究。与CNTs的血管毒性相关的机制仍知之甚少，而且似乎可能涉及多个信号通路。碳纳米管对血管系统的毒性可通过控制碳纳米管的理化特性，特别是长度，直径和表面化学性质来降低。目前，碳纳米管对血管系统的有利和不利影响仍是未知之数，需要进一步的广泛研究。与CNTs的血管毒性相关的机制仍知之甚少，而且似乎可能涉及多个信号通路。碳纳米管对血管系统的毒性可通过控制碳纳米管的物理化学性质，特别是长度，直径和表面化学性质来降低。目前，碳纳米管对血管系统的有利和不利影响仍是未知之数，需要进一步的广泛研究。

更新日期：2019-11-01

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