Globally, liver cancer is the most frequent fatal malignancy; in the United States, it ranks fifth. Patients are often diagnosed with liver cancer in advanced stages, contributing to its poor prognosis. Of all liver cancer cases, >90% are hepatocellular carcinomas (HCCs) for which chemotherapy and immunotherapy are the best options for therapy. For liver cancer patients, new treatment options are necessary. Use of natural compounds and/or nanotechnology may provide patients with better outcomes with lower systemic toxicity and fewer side effects. Improved treatments can lead to better prognoses. Finally, in this review, we present some of the problems and current treatment options contributing to the poor outcomes for patients with liver cancer.

中文翻译：

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肝癌的挑战和可能的治疗方法。


在全球范围内，肝癌是最常见的致命恶性肿瘤。在美国，排名第五。患者常常在晚期被诊断出肝癌，导致其预后不良。在所有肝癌病例中，>90% 是肝细胞癌 (HCC)，化疗和免疫疗法是最佳治疗选择。对于肝癌患者来说，新的治疗方案是必要的。使用天然化合物和/或纳米技术可以为患者提供更好的治疗效果、更低的全身毒性和更少的副作用。改进的治疗可以带来更好的预后。最后，在这篇综述中，我们提出了一些导致肝癌患者预后不良的问题和当前的治疗方案。