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From physics to physiology at the membrane-motor interface.
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2020-02-01 , DOI: 10.1038/s41580-019-0189-0
Roop Mallik 1
Affiliation  

Force-generating motor proteins usually assemble on lipid membranes inside cells. We argue that it is important to consider this membrane as a dynamic entity that responds to cellular and metabolic demands in a manner that harnesses the force from motors to control pathogen degradation, cancer metastasis, lipid homeostasis and possibly other functions relevant to health and physiology. Roop Mallik argues for the importance of considering the impact that membrane lipids have on motors, and the dynamics of the membrane–motor interface, in studies of cytoskeletal motors.

中文翻译:

在膜-运动界面上从物理学到生理学。

产生动力的运动蛋白通常在细胞内部的脂质膜上组装。我们认为重要的是,将这种膜视为动态实体,以利用细胞的力来控制病原体降解,癌症转移,脂质稳态以及可能与健康和生理相关的其他功能的方式来响应细胞和代谢需求。罗普·马利克(Roop Mallik)认为,在细胞骨架运动研究中,必须考虑膜脂对运动的影响以及膜-运动界面的动力学。
更新日期:2019-11-01
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