Previous research in patients with psychotic disorder has shown widespread abnormalities in brain activation during reward anticipation. Research at the level of subclinical psychotic experiences in individuals unexposed to antipsychotic medication is limited with inconclusive results. Therefore, brain activation during reward anticipation was examined in a larger sample of individuals with subclinical psychotic experiences (PE). Participants in the PE-group were included based on CAPE scores. A sample of emerging adults aged 16-26 years (n = =47) with PE and healthy controls (HC) (n = =40) underwent fMRI scanning. The Monetary Incentive Delay task was conducted with cues related to win, loss or neutral conditions. fMRI nonparametric tests were used to examine the reward versus neutral cue contrast. A significant main effect of the large win (€3.00) > neutral contrast was found in both groups showing activation in many brain areas, including classic reward regions. Whole brain analysis on the group comparison regarding the large win > neutral contrast showed significantly decreased activation in the right insula, putamen and supramarginal gyrus in the PE-group compared to controls. There was no group difference in the hypothesized reward-related region. Decreased activation in the right insula, putamen and supramarginal gyrus during reward anticipation in individuals with PE may be consistent with altered processing of sensory information, related to decreased emotional valuing and motivational tendencies and/or altered motor-cognitive processes. The absence of group differences in striatal activation suggests that activation here is intact in the earliest stages of psychosis and may exhibit progressive deterioration in as the disease develops.

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对有亚临床精神病经历的个体的奖励预期：一种功能性 MRI 方法

先前对精神病患者的研究表明，在奖赏预期期间大脑激活普遍存在异常。对未接触抗精神病药物的个体的亚临床精神病经历水平的研究有限，结果尚无定论。因此，在具有亚临床精神病经历 (PE) 的更大样本中检查了奖励预期期间的大脑激活。根据 CAPE 分数包括 PE 组的参与者。对年龄在 16-26 岁（n = = 47）的 PE 和健康对照（HC）（n = = 40）的新兴成年人进行了 fMRI 扫描。货币激励延迟任务是根据与赢、输或中立条件相关的线索进行的。fMRI 非参数检验用于检查奖励与中性线索对比。大赢的显着主效应（€3. 00) > 在两组中都发现了中性对比，显示了许多大脑区域的激活，包括经典奖励区域。对大赢 > 中性对比的组比较的全脑分析显示，与对照组相比，PE 组右脑岛、壳核和边缘上回的激活显着降低。在假设的奖励相关区域中没有组差异。PE 患者在奖赏预期期间右脑岛、壳核和缘上回的激活减少可能与感觉信息处理的改变一致，与情绪评价和动机倾向的降低和/或运动认知过程的改变有关。