Adaptor protein (AP) complexes are heterotetramers that select cargo for inclusion into transport vesicles. Five AP complexes (AP-1 to AP-5) have been described, each with a distinct localisation and function. Furthermore, patients with a range of disorders, particularly involving the nervous system, have now been identified with mutations in each of the AP complexes. In many cases this has been correlated with aberrantly localised membrane proteins. In this Cell Science at a Glance article and the accompanying poster, we summarize what is known about the five AP complexes and discuss how this helps to explain the clinical features of the different genetic disorders.

中文翻译：

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接头蛋白复合物和疾病一目了然。

衔接蛋白 (AP) 复合物是异源四聚体，用于选择货物以纳入运输囊泡。已经描述了五个 AP 复合体（AP-1 到 AP-5），每个都具有不同的定位和功能。此外，现在已经鉴定出患有一系列疾病的患者，特别是涉及神经系统的疾病，每个 AP 复合物都有突变。在许多情况下，这与异常定位的膜蛋白相关。在这篇细胞科学概览文章和随附的海报中，我们总结了关于五种 AP 复合物的已知信息，并讨论这如何有助于解释不同遗传疾病的临床特征。