OBJECTIVES The nature of past cytomegalovirus (CMV) infection in multiple sclerosis (MS) populations is relatively unexplored. Relationships between CMV infection markers and Epstein-Barr virus (EBV) infection markers in a UK resident population of people with MS (PwMS) and controls have been investigated. METHODS CMV and EBV nuclear antigen-1(EBNA-1)/virus capsid antigen (VCA) IgG levels were determined for 78 MS patients and anonymised controls by enzyme immunoassays. CMV IgG levels were expressed as Paul Ehrlich Institute (PEI) units/ml (U/ml) and EBNA-1/VCA IgG levels as enzyme units/ml. RESULTS CMV IgG seroprevalence was lower (p = 0.0003) in PwMS (35.9% [95%CI: 25.2-46.5]) compared to controls (62.9% [95%CI:54.4-71.4). CMV IgG geometric mean levels in PwMS (353 PEI U/ml [95%CI:272-457]) were lower (p = 0.03) compared to the controls (492 PEI U/ml [95%CI:405-599]). EBNA-1 IgG levels were higher (p < 0.0001) in PwMS compared to the controls and were lower (p = 0.238) in CMV seropositive PwMS (49.4 units/ml [95%CI:32.2-75.6]) compared to CMV seronegative PwMS (65.4 units/ml [95%CI:53.4-80.1]). These effects were not apparent with EBV VCA IgG. CONCLUSIONS Several aspects of CMV and EBV infection in PwMS appear to differ compared to controls. The potential immunomodulatory effect of CMV infection on MS disease and potential interactions with EBV require further investigation.

中文翻译：

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与对照组相比，英国多发性硬化症（PwMS）患者对巨细胞病毒（CMV）和爱泼斯坦-巴尔病毒（EBV）感染的反应不同。

目的过去在多发性硬化症（MS）人群中巨细胞病毒（CMV）感染的性质尚未得到开发。在英国MS居民（PwMS）和对照人群中，已经调查了CMV感染标志物和爱泼斯坦-巴尔病毒（EBV）感染标志物之间的关系。方法采用酶联免疫法测定78例MS患者和匿名对照的CMV和EBV核抗原-1（EBNA-1）/病毒衣壳抗原（VCA）IgG水平。CMV IgG水平表示为Paul Ehrlich Institute（PEI）单位/ ml（U / ml），而EBNA-1 / VCA IgG水平表示为酶单位/ ml。结果与对照组（62.9％[95％CI：54.4-71.4]）相比，PwMS中的CMV IgG血清阳性率较低（p = 0.0003）（35.9％[95％CI：25.2-46.5]）。PwMS中的CMV IgG几何平均水平较低（353 PEI U / ml [95％CI：272-457]）（p = 0。03）与对照相比（492 PEI U / ml [95％CI：405-599]）。与CMV血清阴性PwMS相比，PwMS中的EBNA-1 IgG水平较高（p <0.0001），而CMV血清阳性PwMS（49.4单位/ ml [95％CI：32.2-75.6]）较低（p = 0.238） （65.4单位/毫升[95％CI：53.4-80.1]）。这些作用对于EBV VCA IgG并不明显。结论与对照组相比，PwMS中CMV和EBV感染的几个方面似乎有所不同。CMV感染对MS疾病的潜在免疫调节作用以及与EBV的潜在相互作用尚需进一步研究。这些作用对于EBV VCA IgG并不明显。结论与对照组相比，PwMS中CMV和EBV感染的几个方面似乎有所不同。CMV感染对MS疾病的潜在免疫调节作用以及与EBV的潜在相互作用尚需进一步研究。这些作用对于EBV VCA IgG并不明显。结论与对照组相比，PwMS中CMV和EBV感染的几个方面似乎有所不同。CMV感染对MS疾病的潜在免疫调节作用以及与EBV的潜在相互作用尚需进一步研究。