Methylphenidate in children with monogenic obesity due to LEPR or MC4R deficiency improves feeling of satiety and reduces BMI-SDS-A case series.,Pediatric Obesity

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Methylphenidate in children with monogenic obesity due to LEPR or MC4R deficiency improves feeling of satiety and reduces BMI-SDS-A case series.
Pediatric Obesity ( IF 2.7 ) Pub Date : 2019-10-31 , DOI: 10.1111/ijpo.12577
Stephanie Brandt ₁ , Julia von Schnurbein ₁ , Belinda Lennerz _{1,

2} , Katja Kohlsdorf ₁ , Heike Vollbach _{1,

3} , Christian Denzer ₁ , Harald Bode ₄ , Johannes Hebebrand ₅ , Martin Wabitsch ₁

Affiliation

The clinical phenotype of patients with monogenic obesity due to mutations in the leptin receptor (LEPR) or melanocortin 4 receptor (MC4R) gene is characterized by impaired satiety and hyperphagia, leading to extreme, sometimes life‐threatening weight gain.

中文翻译：

由于 LEPR 或 MC4R 缺乏导致的单基因肥胖儿童的哌甲酯可改善饱腹感并减少 BMI-SDS-A 病例系列。

由于瘦素受体 ( LEPR)或黑皮质素 4 受体 ( MC4R ) 基因突变导致的单基因肥胖患者的临床表型以饱腹感受损和食欲亢进为特征，导致体重极度增加，有时甚至危及生命。

更新日期：2019-10-31

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