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Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer
Phytochemistry ( IF 3.2 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.phytochem.2019.112184 Ting Huang 1 , Sheng-Hui Ying 1 , Jing-Ya Li 2 , Hao-Wei Chen 1 , Yi Zang 2 , Wen-Xuan Wang 3 , Jia Li 2 , Juan Xiong 1 , Jin-Feng Hu 1
Phytochemistry ( IF 3.2 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.phytochem.2019.112184 Ting Huang 1 , Sheng-Hui Ying 1 , Jing-Ya Li 2 , Hao-Wei Chen 1 , Yi Zang 2 , Wen-Xuan Wang 3 , Jia Li 2 , Juan Xiong 1 , Jin-Feng Hu 1
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An extensive phytochemical investigation on the chemical constituents from the needles and twigs of the vulnerable conifer Pseudotsuga sinensis yielded 19 diterpenoids and 21 sesquiterpenoids with various carbocyclic skeletons. Among them, 13 (named pseudosinins A-M, resp.) were undescribed compounds. Their structures with absolute configurations were characterized by a combination of spectroscopic methods, calculated and experimental electronic circular dichroism (ECD) data, quantum chemical calculations of the chemical shifts, and single crystal X-ray diffraction analyses. In particular, an array of labdane-derived norditerpenoids with C19-, C18-, and C16-skeletons, and related drimane-type sesquitepenoids with C15- and C13-skeletons were found in the title plant. The possible biogenetic relationships of these degraded terpenoids were briefly discussed. Among the isolates, pseudosinin D, cis-communic acid, and 4β,15-dihydroxy-19-norabieta-8,11,13-trien-7-one showed moderate inhibitory activities against the enzyme ATP-citrate lyase (ACL), a potential drug target for the treatment of hyperlipidemia and hypercholesterolemia.
更新日期：2020-01-01
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