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Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth
Phytochemistry ( IF 3.2 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.phytochem.2019.112185
Toshio Morikawa 1 , Yusuke Nakanishi 2 , Naoki Inoue 2 , Yoshiaki Manse 2 , Hideyuki Matsuura 2 , Shinya Hamasaki 2 , Masayuki Yoshikawa 2 , Osamu Muraoka 1 , Kiyofumi Ninomiya 1
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Seven new acylated iridoid glycosides, picrorhizaosides A-G (1-7), were isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae), in addition to six known iridoid glycosides (8-13). The structures of these new iridoids, including their stereochemistry, were determined based on chemical and physicochemical evidence derived from NMR and MS analysis. Of the isolates, picrorhizaosides D (4, IC50 = 43.4 μM) and E (5, 35.8 μM); picrosides I (8, 60.7 μM), II (9, 22.3 μM), and IV (11, 59.2 μM); and minecoside (13, 57.2 μM), exhibited a similar or stronger hyaluronidase inhibitory activity than those of the antiallergic medicines disodium cromoglycate (64.8 μM), ketotifen fumarate (76.5 μM), and tranilast (227 μM).

中文翻译:

来自 Picrorhiza kurroa Royle ex Benth 根茎的具有透明质酸酶抑制活性的酰化环烯醚萜苷

七种新的酰化环烯醚萜苷,picrorhizaosides AG (1-7),是从 Picrorhiza kurroa Royle ex Benth 根茎的甲醇提取物中分离出来的。(车前草科),此外还有六种已知的环烯醚萜苷 (8-13)。这些新环烯醚萜类化合物的结构,包括它们的立体化学,是根据来自 NMR 和 MS 分析的化学和物理化学证据确定的。在分离株中,苦根皂苷 D (4, IC50 = 43.4 μM) 和 E (5, 35.8 μM);苦甙 I (8, 60.7 μM)、II (9, 22.3 μM) 和 IV (11, 59.2 μM);和 minecoside (13, 57.2 μM) 表现出与抗过敏药物色甘酸二钠 (64.8 μM)、富马酸酮替芬 (76.5 μM) 和曲尼司特 (227 μM) 相似或更强的透明质酸酶抑制活性。
更新日期:2020-01-01
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