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Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth
Phytochemistry ( IF 3.2 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.phytochem.2019.112185 Toshio Morikawa 1 , Yusuke Nakanishi 2 , Naoki Inoue 2 , Yoshiaki Manse 2 , Hideyuki Matsuura 2 , Shinya Hamasaki 2 , Masayuki Yoshikawa 2 , Osamu Muraoka 1 , Kiyofumi Ninomiya 1
Phytochemistry ( IF 3.2 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.phytochem.2019.112185 Toshio Morikawa 1 , Yusuke Nakanishi 2 , Naoki Inoue 2 , Yoshiaki Manse 2 , Hideyuki Matsuura 2 , Shinya Hamasaki 2 , Masayuki Yoshikawa 2 , Osamu Muraoka 1 , Kiyofumi Ninomiya 1
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Seven new acylated iridoid glycosides, picrorhizaosides A-G (1-7), were isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae), in addition to six known iridoid glycosides (8-13). The structures of these new iridoids, including their stereochemistry, were determined based on chemical and physicochemical evidence derived from NMR and MS analysis. Of the isolates, picrorhizaosides D (4, IC50 = 43.4 μM) and E (5, 35.8 μM); picrosides I (8, 60.7 μM), II (9, 22.3 μM), and IV (11, 59.2 μM); and minecoside (13, 57.2 μM), exhibited a similar or stronger hyaluronidase inhibitory activity than those of the antiallergic medicines disodium cromoglycate (64.8 μM), ketotifen fumarate (76.5 μM), and tranilast (227 μM).
中文翻译：
来自 Picrorhiza kurroa Royle ex Benth 根茎的具有透明质酸酶抑制活性的酰化环烯醚萜苷
七种新的酰化环烯醚萜苷，picrorhizaosides AG (1-7)，是从 Picrorhiza kurroa Royle ex Benth 根茎的甲醇提取物中分离出来的。（车前草科），此外还有六种已知的环烯醚萜苷 (8-13)。这些新环烯醚萜类化合物的结构，包括它们的立体化学，是根据来自 NMR 和 MS 分析的化学和物理化学证据确定的。在分离株中，苦根皂苷 D (4, IC50 = 43.4 μM) 和 E (5, 35.8 μM)；苦甙 I (8, 60.7 μM)、II (9, 22.3 μM) 和 IV (11, 59.2 μM)；和 minecoside (13, 57.2 μM) 表现出与抗过敏药物色甘酸二钠 (64.8 μM)、富马酸酮替芬 (76.5 μM) 和曲尼司特 (227 μM) 相似或更强的透明质酸酶抑制活性。
更新日期：2020-01-01
中文翻译：
来自 Picrorhiza kurroa Royle ex Benth 根茎的具有透明质酸酶抑制活性的酰化环烯醚萜苷
七种新的酰化环烯醚萜苷，picrorhizaosides AG (1-7)，是从 Picrorhiza kurroa Royle ex Benth 根茎的甲醇提取物中分离出来的。（车前草科），此外还有六种已知的环烯醚萜苷 (8-13)。这些新环烯醚萜类化合物的结构，包括它们的立体化学，是根据来自 NMR 和 MS 分析的化学和物理化学证据确定的。在分离株中，苦根皂苷 D (4, IC50 = 43.4 μM) 和 E (5, 35.8 μM)；苦甙 I (8, 60.7 μM)、II (9, 22.3 μM) 和 IV (11, 59.2 μM)；和 minecoside (13, 57.2 μM) 表现出与抗过敏药物色甘酸二钠 (64.8 μM)、富马酸酮替芬 (76.5 μM) 和曲尼司特 (227 μM) 相似或更强的透明质酸酶抑制活性。
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