Background

Fish oil enriched in omega-11 long-chain monounsaturated fatty acids (LCMUFAs; C20:1 and C22:1 isomers combined) have shown lipid-lowering and atheroprotective effects in animal models.

Objective

To perform a first-in-human trial of LCMUFA-rich saury fish oil supplementation to test its safety and possible effect on plasma lipids.

Methods

A double-blind, randomized, crossover clinical trial was carried out in 30 healthy normolipidemic adults (BMI <25 kg/m²; mean TG, 84 mg/dL). Treatment periods of 8 weeks were separated by an 8-week washout period. Subjects were randomized to receive either 12 g of saury oil (3.5 g of LCMUFA and 3.4 g of omega-3 FAs) or identical capsules with control oil (a mixture of sardine and olive oil; 4.9 g of shorter-chain MUFA oleate and 3 g of omega-3 FAs).

Results

Saury oil supplementation was safe and resulted in LDL particle counts 12% lower than control oil (P < .001). Saury oil also had a minor effect on increasing HDL particle size (9.8 nm vs 9.7 nm; P < .05) based on a linear mixed effect model. In contrast, control oil, but not saury oil, increased LDL-C by 7.5% compared with baseline (P < .05). Saury oil had similar effects compared with control oil on lowering plasma TG levels, VLDL, and TG-rich lipoprotein particle counts (by ∼16%, 25%, and 35%, respectively; P < .05), and increasing HDL-C and cholesterol efflux capacity (by ∼6% and 8%, respectively; P < .05) compared with baseline.

Conclusion

Saury oil supplementation is well tolerated and has beneficial effects on several cardiovascular parameters, such as LDL particle counts, HDL particle size, and plasma TG levels.

中文翻译：

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补充秋刀鱼油（一种富含 omega-11 单不饱和脂肪酸的鱼油）可改善健康受试者的血浆脂质。

背景

富含 omega-11 长链单不饱和脂肪酸（LCMUFA；C20:1 和 C22:1 异构体组合）的鱼油在动物模型中显示出降脂和动脉粥样硬化作用。

客观的

对富含 LCMUFA 的秋刀鱼鱼油补充剂进行首次人体试验，以测试其安全性和对血脂的可能影响。

方法

^{在 30 名健康血脂正常的成年人（BMI <25 kg/m 2} ；平均 TG，84 mg/dL）中进行了一项双盲、随机、交叉临床试验。8 周的治疗期被 8 周的清除期分开。受试者随机接受 12 克秋刀鱼油（3.5 克 LCMUFA 和 3.4 克 omega-3 FA）或相同的对照油胶囊（沙丁鱼和橄榄油的混合物；4.9 克短链 MUFA 油酸酯和 3 克）。 g omega-3 FA）。

结果

补充秋刀鱼油是安全的，LDL 颗粒计数比对照油低 12% ( P  < .001)。 根据线性混合效应模型，秋刀鱼油对增加 HDL 粒径也有轻微影响（9.8 nm 与 9.7 nm；P < .05）。相比之下，与基线相比，对照油（而非秋刀鱼油）使 LDL-C 增加了 7.5%（P  < .05）。与对照油相比，秋刀鱼油在降低血浆 TG 水平、VLDL 和富含 TG 的脂蛋白颗粒计数方面具有相似的效果（分别降低约 16%、25% 和 35%；P  < .05），并增加 HDL-C与基线相比，胆固醇流出能力（分别增加约 6% 和 8%；P  < .05）。

结论

秋刀鱼油补充剂具有良好的耐受性，并且对多种心血管参数有有益影响，例如低密度脂蛋白颗粒计数、高密度脂蛋白颗粒大小和血浆甘油三酯水平。