New Jersey (NJ) residents in some areas may be exposed to perfluoroalkyl and polyfluoroalkyl substances (PFAS) due to PFAS contamination of public drinking water. This contamination stems from industrial discharges and the use of aqueous film-foaming foams at military bases and commercial airports for drills and locations where fires occurred. Exposure to PFAS has raised significant public health concerns due to its persistence both in the environment and human body. The potential toxicity of these chemicals may pose risks to human health. Statewide biomonitoring data is needed to establish a baseline of exposure and to identify the subpopulations at risk. The NJ Department of Health (NJDOH) conducted a statewide NJ Biomonitoring (NJBM) study for PFAS utilizing a cost-effective sampling approach, i.e. acquiring remnant sera from both clinical laboratories and blood banks across NJ. This convenience sampling approach was adopted as an alternative to a costly and labor-intensive probability-based population sampling. One thousand and thirty human sera were collected from NJ adults between 20 and 74 years of age from 2016 to 2018, with additional information of county, sex, and age. The serum collection was demographically and geographically dispersed across four seasons. Twelve PFAS analytes were measured for the specimens collected. The data were post-stratified by county, sex, and age groups (20–39, 40–59, and 60–74 years old). Stratified individual sample weights were developed and used to estimate population means, compare least-squared mean differences, and examine contributing variables. Geometric means (GMs) and percentiles with 95% confidence intervals (CIs) of the target analytes are presented, providing preliminary baselines of the statewide PFAS exposure for NJ adults. PFOA, PFNA, PFHxS, and PFOS were selected for in-depth analyses because their GMs were greater than 0.5 ng/mL and they were detected over 99% in study population. Subjects from this study had higher serum levels of PFOA, PFNA, and PFHxS compared to the general U.S. population reported by the latest National Health and Nutrition Examination Survey (NHANES in 2015–2016). However, the distributions of PFOA, PFNA, PFHxS, and PFOS across sex and age groups were consistent with the patterns found in NHANES, i.e. all differed by sex and age group. Further sex and age stratification showed significantly lower concentrations of the 4 analytes in younger females (20–59 years old) than in older females (60–74 years old) and males (20–74 years old). Future research is needed to identify PFAS exposure sources and to develop effective intervention strategies. Continuing PFAS biomonitoring using population sampling is recommended for tracking trends and better identifying subpopulations at risk.

由于PFAS对公共饮用水的污染，某些地区的新泽西州（NJ）居民可能会暴露于全氟烷基和多氟烷基物质（PFAS）。这种污染源于工业排放以及军事基地和商业机场在演习和发生火灾的地点使用水性泡沫薄膜泡沫。由于全氟辛烷磺酸在环境和人体中的持久性，暴露于全氟辛烷磺酸引起了重大的公共卫生关注。这些化学物质的潜在毒性可能对人体健康构成威胁。需要建立州范围内的生物监测数据，以建立暴露基准并确定处于危险中的亚群。新泽西州卫生部（NJDOH）使用经济有效的抽样方法对全氟辛烷磺酸进行了全州范围的新泽西州生物监测（NJBM）研究。从新泽西州的临床实验室和血库中获取残留血清。这种便捷的抽样方法被用来替代昂贵且劳动密集型的基于概率的人口抽样。从2016年到2018年，从20至74岁之间的新泽西州成年人中收集了130份人类血清，并提供了县，性别和年龄的其他信息。血清收集在人口和地理上分布于四个季节。测量了十二种PFAS分析物的样本。数据按县，性别和年龄组（20-39岁，40-59岁和60-74岁）分类。开发了分层的个体样本权重，并将其用于估计总体均值，比较最小二乘均值差并检查贡献变量。给出了目标分析物的95％置信区间（CIs）的几何平均值（GMs）和百分位数，为新泽西州成年人提供全州PFAS暴露的初步基线。选择PFOA，PFNA，PFHxS和PFOS进行深入分析，因为它们的GMs大于0.5 ng / mL，在研究人群中检出率超过99％。这项研究的受试者的PFOA，PFNA和PFHxS血清水平高于最新的美国国家健康与营养调查（NHANES in 2015-2016）报告的全美人群。但是，PFOA，PFNA，PFHxS和PFOS在性别和年龄组中的分布与NHANES中发现的模式一致，即，在性别和年龄组中均存在差异。进一步的性别和年龄分层显示，年轻女性（20-59岁）中的4种分析物的浓度显着低于老年女性（60-74岁）和男性（20-74岁）。需要进一步的研究来确定PFAS的暴露源并制定有效的干预策略。建议继续使用人群抽样进行PFAS生物监测，以追踪趋势并更好地识别处于危险中的亚群。