Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs with a closed loop structure. These RNAs are produced by pre-mRNA through variable shear processing and are highly conserved. Such highly conserved molecules play an important role in biology, especially in cancer biology. With the development of experimental techniques such as circRNA microarray screening and high-throughput sequencing technologies, the mystery of circRNAs has gradually been unveiled and the values of function and application have gradually emerged. Among them, cancer-related circRNAs are the most eye-catching. Numerous studies have shown that some circRNAs were involved in the pathogenesis of cancer. This review systematically introduced the cancer-related circRNAs and their origin, formation mechanisms, functions, and applications in the diagnosis and treatment of sixteen kinds of tumors.

环状RNA（circRNA）是一类具有闭环结构的内源性非编码RNA。这些RNA由前体mRNA通过可变剪切加工产生，并且高度保守。这种高度保守的分子在生物学中，特别是在癌症生物学中起着重要的作用。随着circRNA芯片筛选和高通量测序技术等实验技术的发展，circRNA的奥秘逐渐暴露，功能和应用价值逐渐显现。其中，与癌症相关的circRNA最引人注目。大量研究表明，某些circRNA与癌症的发病机制有关。这篇综述系统地介绍了与癌症相关的circRNA及其起源，形成机制，功能，