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DNA hydrogel-empowered biosensing.
Advances in Colloid and Interface Science ( IF 15.9 ) Pub Date : 2019-10-31 , DOI: 10.1016/j.cis.2019.102060
Sima Khajouei 1 , Hadi Ravan 1 , Ali Ebrahimi 1
Affiliation  

DNA hydrogels as special members in the DNA nanotechnology have provided crucial prerequisites to create innovative gels owing to their sufficient stability, biocompatibility, biodegradability, and tunable multifunctionality. These properties have tailored DNA hydrogels for various applications in drug delivery, tissue engineering, sensors, and cancer therapy. Recently, DNA-based materials have attracted substantial consideration for the exploration of smart hydrogels, in which their properties can change in response to chemical or physical stimuli. In other words, these gels can undergo switchable gel-to-sol or sol-to-gel transitions upon application of different triggers. Moreover, various functional motifs like i-motif structures, antisense DNAs, DNAzymes, and aptamers can be inserted into the polymer network to offer a molecular recognition capability to the complex. In this manuscript, a comprehensive discussion will be endowed with the recognition capability of different kinds of DNA hydrogels and the alternation in physicochemical behaviors upon target introducing. Finally, we offer a vision into the future landscape of DNA based hydrogels in sensing applications.

中文翻译:

DNA 水凝胶赋能生物传感。

DNA 水凝胶作为 DNA 纳米技术中的特殊成员,由于其足够的稳定性、生物相容性、生物降解性和可调节的多功能性,为创造创新凝胶提供了重要的先决条件。这些特性为药物输送、组织工程、传感器和癌症治疗中的各种应用定制了 DNA 水凝胶。最近,基于 DNA 的材料在智能水凝胶的探索中引起了广泛关注,在这种水凝胶中,它们的特性可以响应化学或物理刺激而发生变化。换句话说,这些凝胶可以在应用不同的触发器时经历可切换的凝胶到溶胶或溶胶到凝胶的转变。此外,各种功能基序如 i-motif 结构、反义 DNA、脱氧核酶、适配体可以插入到聚合物网络中,为复合物提供分子识别能力。在这份手稿中,将全面讨论不同种类的 DNA 水凝胶的识别能力和目标引入后物理化学行为的变化。最后,我们展望了基于 DNA 的水凝胶在传感应用中的未来前景。
更新日期:2019-11-01
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