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Non-pharmacological therapeutic strategy options for patients with dementia based on cognitive function-A Bayesian network meta-analysis of randomized controlled trials.
Ageing Research Reviews ( IF 12.5 ) Pub Date : 2019-10-31 , DOI: 10.1016/j.arr.2019.100965
Jing-Hong Liang 1 , Lu Lin 2 , Ying-Quan Wang 3 , Rui-Xia Jia 4 , Xin-Yuan Qu 5 , Jing Li 1 , Jia-Yu Li 1 , Sheng Qian 3 , Yu-Xi Qian 3 , Shan Wang 3 , Zhen Gao 6 , Xing-Xue Cheng 3 , Yong Xu 1
Affiliation  

Dementia represents one of the most common neurodegenerative disorders in older adults. However, it is still unclear whether non-pharmacological therapies (NPTs) are effective or not and which treatment should be preferred. We applied a series of search strategies to identify eligible randomized controlled trials on 1st October, 2018, investigating the effects of NPTs of dementia in the older persons. Pairwise and network meta-analyses were sequentially performed. A total of 31 trials were included, which enrolled 1895 participants and 7 NPTs. Compared with control group, all the NPTs included were statistically beneficial to cognitive function, and our study indicated Comprehensive Therapy(CT) [the surface under the cumulative ranking curve (SUCRA = 92.42%)] might be the best choice for dementia patients. Our study suggests CT might be the optimal NPT for improving the cognitive function of dementia patients. However, the above conclusions need to be further analyzed.



中文翻译:

基于认知功能的痴呆患者的非药物治疗策略选择-随机对照试验的贝叶斯网络荟萃分析。

痴呆症是老年人中最常见的神经退行性疾病之一。但是,尚不清楚非药物疗法(NPT)是否有效,应首选哪种疗法。我们于2018年10月1日应用了一系列搜索策略来确定合格的随机对照试验,以调查老年痴呆症的NPT的影响。成对和网络荟萃分析依次进行。总共包括31个试验,招募了1895名参与者和7个《不扩散核武器条约》。与对照组相比,纳入的所有NPT对认知功能均具有统计学意义,我们的研究表明综合疗法(CT)[累积排名曲线下的表面(SUCRA = 92.42%)]可能是痴呆症患者的最佳选择。我们的研究表明CT可能是改善痴呆患者认知功能的最佳NPT。但是,以上结论有待进一步分析。

更新日期:2019-10-31
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