Cellular senescence is a stress response that limits the proliferation of damaged cells by establishing a permanent cell cycle arrest. Different stimuli can trigger senescence but excessive production or impaired clearance of these cells can lead to their accumulation during aging with deleterious effects. Despite this potential negative side of cell senescence, its physiological role as a pro‐regenerative and morphogenetic force has emerged recently after the identification of programmed cell senescence during embryogenesis and during wound healing and limb regeneration. Here, we explored the conservation of tissue injury‐induced senescence in a model of complex regeneration, the zebrafish. Fin amputation in adult fish led to the appearance of senescent cells at the site of damage, and their removal impaired tissue regeneration. Despite many conceptual similarities, this tissue repair response is different from developmental senescence. Our results lend support to the notion that cell senescence is a positive response promoting tissue repair and homeostasis.

中文翻译：

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细胞衰老有助于斑马鱼的组织再生。

细胞衰老是一种应激反应，它通过建立永久性的细胞周期停滞来限制受损细胞的增殖。不同的刺激会触发衰老，但是这些细胞的过度生产或清除能力受损会导致它们在衰老过程中积聚，并产生有害影响。尽管可能存在细胞衰老的不利方面，但在胚胎形成过程中以及伤口愈合和肢体再生过程中确定了程序性细胞衰老后，其作为促再生和形态发生力的生理作用最近才出现。在这里，我们探索了斑马鱼这种复杂再生模型中组织损伤引起的衰老的保守性。成年鱼的肢端截肢导致在损伤部位出现衰老细胞，去除它们会损害组织的再生。尽管在概念上有许多相似之处，但这种组织修复反应与发育衰老有所不同。我们的结果支持以下观点：细胞衰老是促进组织修复和体内稳态的阳性反应。