Advances in microbial production of medium-chain dicarboxylic acids for nylon materials,Reaction Chemistry & Engineering

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Advances in microbial production of medium-chain dicarboxylic acids for nylon materials
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2019/10/31 , DOI: 10.1039/c9re00338j
Guohui Li _{1,

2,

3,

4,

5} , Dixuan Huang _{1,

2,

3,

4,

5} , Xue Sui _{1,

2,

3,

4,

5} , Shiyun Li _{1,

2,

3,

4,

5} , Bing Huang _{4,

6,

7,

8,

9} , Xiaojuan Zhang _{1,

2,

3,

4,

5} , Hui Wu _{4,

6,

7,

8,

9} , Yu Deng _{1,

2,

3,

4,

5}

Affiliation

Medium-chain dicarboxylic acids (MDCAs) are widely used in the production of nylon materials such as nylon 5,6 and nylon 6,6, and among which, succinic, glutaric, adipic, pimelic, suberic, azelaic and sebacic acids are particularly important for that purpose, and also serve as platform chemicals for chemical, food, textile, pesticide, pharmaceutical and liquid crystal industries. Although most of these MDCAs are chemically synthesized, their biosynthesis has become more important due to the fast growth of biotechnology. Compared with chemical production and plant extraction, microbial-based production is more environmentally friendly and sustainable. In this review article, we critically comment existing methods for producing MDCAs and their biosynthesis, emphasizing metabolic engineering and synthetic biology strategies, which could help overcome barriers ahead and facilitate efficient bio-based production of MDCAs in the future.

中文翻译：

尼龙材料中链二元羧酸的微生物生产进展

中链二羧酸（MDCA）被广泛用于尼龙材料的生产，例如尼龙5,6和尼龙6,6，其中，琥珀酸，戊二酸，己二酸，庚二酸，辛二酸，壬二酸和癸二酸尤为重要为此，还可以用作化工，食品，纺织，农药，制药和液晶行业的平台化学品。尽管大多数MDCA是化学合成的，但由于生物技术的快速发展，其生物合成变得越来越重要。与化学生产和植物提取相比，基于微生物的生产更加环保和可持续。在这篇评论文章中，我们对生产MDCA及其生物合成的现有方法进行了批判性评论，强调了代谢工程和合成生物学策略，

更新日期：2020-02-13

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