Substantial and durable weight loss can lead to remission of type 2 diabetes for some individuals who are overweight or obese, with huge potential health benefits. In The Lancet Diabetes & Endocrinology, Dag Hofsø and colleagues report results from the Oseberg study, which take us an important step closer to realising this potential. In a well-designed randomised controlled trial, the investigators show that gastric bypass is associated with a higher remission rate of type 2 diabetes than sleeve gastrectomy at 1 year after surgery. The gastric bypass group showed greater weight loss and a higher reduction of total body fat. Both groups showed similar improvement of β-cell function. Based on evidence from several randomised controlled trials, weight loss must now be considered a key component of therapy for overweight or obese people with type 2 diabetes. In the DiRECT study, which assessed the effectiveness of a primary care-based weight-loss intervention involving an intensive dietary programme, a linear relation between weight loss and improvement of glycaemic control was reported.

中文翻译：

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减肥手术和2型糖尿病：距离确定最佳治疗方法还差一步。

大量且持久的体重减轻可能会使某些超重或肥胖的人缓解2型糖尿病，并具有巨大的潜在健康益处。在《柳叶刀糖尿病与内分泌学》中，DagHofsø及其同事报告了Oseberg研究的结果，这使我们朝着实现这一潜力迈出了重要的一步。在一项精心设计的随机对照试验中，研究人员表明，术后1年，胃旁路术与2型糖尿病的缓解率比袖胃切除术更高。胃旁路术组显示出更大的体重减轻和更高的体内总脂肪减少。两组均显示出类似的β细胞功能改善。根据一些随机对照试验的证据，对于超重或肥胖的2型糖尿病患者，现在必须将体重减轻视为治疗的关键组成部分。在DiRECT研究中，评估了涉及强化饮食计划的以初级保健为基础的减肥干预措施的有效性，