The subgingival microbiome associated with periodontitis in type 2 diabetes mellitus.,The ISME Journal

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The subgingival microbiome associated with periodontitis in type 2 diabetes mellitus.
The ISME Journal ( IF 10.8 ) Pub Date : 2019-10-31 , DOI: 10.1038/s41396-019-0544-3
Baochen Shi ₁ , Renate Lux ₂ , Perry Klokkevold ₂ , Michaela Chang ₂ , Emma Barnard ₁ , Susan Haake ₂ , Huiying Li _{1,

3}

Affiliation

Type 2 diabetes mellitus (T2DM) is a systemic disease, predisposing patients to other inflammatory conditions including periodontitis. The subgingival microbiome, a key player in periodontitis pathogenesis, is not well characterized in T2DM population. To better understand whether the subgingival microbiome is different between T2DM and systemically healthy, nondiabetic (ND) subjects, we performed a longitudinal analysis of the subgingival microbiome in T2DM patients (n = 15) compared with ND subjects (n = 16). Using metagenomic shotgun sequencing, we investigated the microbiome in the healthy periodontal state, periodontitis state, and resolved state after treatment. We found that in the periodontitis state, the shift in the subgingival microbiome from the healthy state was less prominent in T2DM compared with ND subjects, yet the clinical signs of disease were similar for both. Furthermore, we revealed highly correlated presence of pathogenic species in relative abundance not only in the periodontitis state, but also in the healthy state in T2DM, suggesting an elevated risk of progression to periodontitis in this cohort. We further investigated the functional potentials of the subgingival microbiome and identified a set of microbial marker genes associated with the clinical states. These genes were significantly enriched in 21 pathways, some of which are associated with periodontitis and some potentially link T2DM and periodontitis. This study identified the longitudinal changes of the subgingival microbiome associated with periodontitis in T2DM and suggests that T2DM patients are more susceptible to shifts in the subgingival microbiome toward dysbiosis, potentially due to impaired host metabolic and immune regulation.

中文翻译：

与 2 型糖尿病牙周炎相关的龈下微生物组。

2 型糖尿病 (T2DM) 是一种全身性疾病，使患者易患其他炎症性疾病，包括牙周炎。牙龈下微生物组是牙周炎发病机制的关键因素，在 T2DM 人群中没有很好的特征。为了更好地了解 T2DM 和全身健康的非糖尿病 (ND) 受试者的龈下微生物群是否不同，我们对 T2DM 患者 (n = 15) 与 ND 受试者 (n = 16) 的龈下微生物群进行了纵向分析。使用宏基因组鸟枪法测序，我们调查了健康牙周状态、牙周炎状态和治疗后消退状态的微生物组。我们发现，在牙周炎状态下，与 ND 受试者相比，T2DM 牙龈下微生物组从健康状态的转变不太明显，然而，两者的疾病临床症状相似。此外，我们发现，不仅在牙周炎状态，而且在 T2DM 的健康状态下，致病物种的相对丰度存在高度相关，这表明该队列中进展为牙周炎的风险升高。我们进一步研究了龈下微生物组的功能潜力，并确定了一组与临床状态相关的微生物标记基因。这些基因在 21 条通路中显着富集，其中一些与牙周炎相关，一些可能与 T2DM 和牙周炎相关。本研究确定了与 T2DM 牙周炎相关的龈下微生物群的纵向变化，并表明 T2DM 患者更容易受到龈下微生物群向菌群失调的影响，

更新日期：2020-01-17

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