The design and biomedical applications of self-assembled two-dimensional organic biomaterials,Chemical Society Reviews

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The design and biomedical applications of self-assembled two-dimensional organic biomaterials
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2019-10-31 , DOI: 10.1039/c8cs01003j
Xiaoyuan Zhang _{1,

2,

3,

4,

5} , Coucong Gong _{6,

7,

8,

9} , Ozioma Udochukwu Akakuru _{10,

11,

12,

13,

14} , Zhiqiang Su _{1,

2,

3} , Aiguo Wu _{10,

11,

12,

13,

14} , Gang Wei _{6,

7,

8,

9,

10}

Affiliation

The design and applications of some inorganic two-dimensional (2D) nanomaterials such as graphene, graphyne, and borophene have been widely studied in recent years. Meanwhile, it has been noticed that self-assembling two-dimensional organic biomaterials (2DOBMs) including films, membranes, nanosheets, nanoribbons, grids, arrays, and lattices based on various biomolecules also exhibited promising structures, functions, and applications. The in-depth studies on the self-assembly formation, structural and functional tailoring of 2DOBMs open new avenues for the next generation of novel nanomaterials with adjustable structure and functions, which would further promote the applications of 2DOBMs in materials science, nanodevices, energy and environmental science, biomedicine, tissue engineering, and analytical science. In this review, we summarize important information on the basic principles to fabricate self-assembling 2DOBMs based on peptides, proteins, DNA, RNA, viruses, and other biopolymers. The potential strategies and techniques for tailoring and controlling the structures and functions of 2DOBMs are presented and discussed further. The function-specific biomedical applications of 2DOBMs in biosensors, biomimetic mineralization, cell growth, drug/gene delivery, and bioimaging are also highlighted.

中文翻译：

自组装二维有机生物材料的设计及生物医学应用

近年来，已经广泛研究了一些无机二维（2D）纳米材料的设计和应用，例如石墨烯，石墨烯和硼苯。同时，已经注意到基于各种生物分子的包括膜，膜，纳米片，纳米带，网格，阵列和晶格的自组装二维有机生物材料（2DOBM）也展现出有希望的结构，功能和应用。对2DOBM的自组装形成，结构和功能定制的深入研究为下一代具有可调结构和功能的新型纳米材料开辟了新途径，这将进一步促进2DOBM在材料科学，纳米器件，能源和能源领域的应用。环境科学，生物医学，组织工程和分析科学。在这篇评论中，我们总结了有关基于肽，蛋白质，DNA，RNA，病毒和其他生物聚合物制造自组装2DOBM的基本原理的重要信息。提出并讨论了用于定制和控制2DOBM的结构和功能的潜在策略和技术。还重点介绍了2DOBM在生物传感器，仿生矿化，细胞生长，药物/基因传递和生物成像中的功能特定的生物医学应用。

更新日期：2019-10-31

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