The effects of deoxyhemoglobin (Hb) and albumin on the NO-donor activity of the anionic tetranitrosyl iron complex with thiosulfate ligands (1) were studied for the first time. It was shown that Hb significantly stabilizes complex 1; in its presence, NO generation from the complex proceeds at a noticeably slower rate. A similar effect is observed when complex 1 is bound to albumin, in which case complex 1 decomposes 27 times slower than in the absence of albumin in the solution. The observed effects provide a prolonged action of complex 1 as NO-donor, which may enhance its potential pharmacological efficacy.

中文翻译：

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血红蛋白和白蛋白对四亚硝基铁配合物硫代硫酸盐的NO给与作用的影响。

首次研究了脱氧血红蛋白（Hb）和白蛋白对带有硫代硫酸盐配体的阴离子四亚硝基铁配合物的NO-给体活性的影响。结果表明，血红蛋白显着稳定了配合物1；在其存在下，复合物的NO生成速度明显降低。当复合物1与白蛋白结合时，观察到类似的效果，在这种情况下，复合物1的分解速度比溶液中不存在白蛋白的分解速度慢27倍。观察到的效果可延长复合物1作为NO供体的作用，这可能会增强其潜在的药理作用。