One of the primary goals in tumor immunotherapy is to reset the immune system from tolerogenic to immunogenic - a process in which invariant natural killer T (iNKT) cells are implicated. iNKT cells develop in the thymus and perform immunosurveillance against tumor cells peripherally. When optimally stimulated, iNKT cells differentiate and display more efficient immune functions. Some cells survive and act as effector memory cells. We discuss the putative roles of iNKT cells in antitumor immunity, and posit that it may be possible to develop novel therapeutic strategies to treat cancers using iNKT cells. In particular, we highlight the challenge of uniquely energizing iNKT cell-licensed dendritic cells to serve as effective immunoadjuvants for both arms of the immune system, thus coupling immunological networks.

中文翻译：

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免疫网络和癌症中iNKT细胞的治疗靶向性。

肿瘤免疫疗法的主要目标之一是将免疫系统从耐受原性重置为免疫原性-这是一个涉及不变的自然杀伤T（iNKT）细胞的过程。iNKT细胞在胸腺中发育，并对周围的肿瘤细胞进行免疫监视。当受到最佳刺激时，iNKT细胞会分化并显示出更有效的免疫功能。一些细胞存活并充当效应记忆细胞。我们讨论了iNKT细胞在抗肿瘤免疫中的假定作用，并认为有可能开发出新的治疗策略来使用iNKT细胞治疗癌症。特别是，我们强调了独特地激发iNKT细胞许可的树突状细胞作为免疫系统两臂的有效免疫佐剂的挑战，从而耦合了免疫网络。