A mechanistic understanding of the diverse clinical manifestations of Parkinson’s disease (PD) and variable patient response to treatments is lacking. Genetically diverse PD model organisms can be used to map modifier genes and understand clinically relevant phenotypes of varying severity. This strategy can accelerate the pace of discoveries for precision medicine purposes.

中文翻译：

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建模帕金森氏病异质性以加速精密医学。

缺乏对帕金森氏病（PD）的各种临床表现以及患者对治疗的反应不一的机械理解。遗传上不同的PD模型生物可用于定位修饰基因并了解不同严重程度的临床相关表型。这种策略可以加快用于精密医学目的的发现速度。