Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2019-10-31 , DOI: 10.1016/j.addr.2019.09.003 Mazaher Gholipourmalekabadi 1 , Sunaina Sapru 2 , Ali Samadikuchaksaraei 1 , Rui L Reis 3 , David L Kaplan 4 , Subhas C Kundu 5
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Several synthetic and natural materials are used in soft tissue engineering and regenerative medicine with varying degrees of success. Among them, silkworm silk protein fibroin, a naturally occurring protein-based biomaterial, exhibits many promising characteristics such as biocompatibility, controllable biodegradability, tunable mechanical properties, aqueous preparation, minimal inflammation in host tissue, low cost and ease of use. Silk fibroin is often used alone or in combination with other materials in various formats and is also a promising delivery system for bioactive compounds as part of such repair scenarios. These properties make silk fibroin an excellent biomaterial for skin tissue engineering and repair applications. This review focuses on the promising characteristics and recent advances in the use of silk fibroin for skin wound healing and/or soft-tissue repair applications. The benefits and limitations of silk fibroin as a scaffolding biomaterial in this context are also discussed.
Statement of significance
Silk protein fibroin is a natural biomaterial with important biological and mechanical properties for soft tissue engineering applications. Silk fibroin is obtained from silkworms and can be purified using alkali or enzyme based degumming (removal of glue protein sericin) procedures. Fibroin is used alone or in combination with other materials in different scaffold forms, such as nanofibrous mats, hydrogels, sponges or films tailored for specific applications. The investigations carried out using silk fibroin or its blends in skin tissue engineering have increased dramatically in recent years due to the advantages of this unique biomaterial. This review focuses on the promising characteristics of silk fibroin for skin wound healing and/or soft-tissue repair applications.
中文翻译：
用于皮肤损伤修复的丝素蛋白：情况如何？
几种合成和天然材料用于软组织工程和再生医学，并取得了不同程度的成功。其中，蚕丝蛋白丝素是一种天然存在的基于蛋白质的生物材料，具有许多有前途的特性，如生物相容性、可控的生物降解性、可调的机械性能、水性制剂、宿主组织中的炎症最小、成本低和易于使用。丝素蛋白通常单独使用或与其他材料以各种形式结合使用，作为此类修复方案的一部分，它也是一种很有前途的生物活性化合物输送系统。这些特性使丝素蛋白成为皮肤组织工程和修复应用的优良生物材料。本综述重点关注丝素蛋白在皮肤伤口愈合和/或软组织修复应用中的应用前景和最新进展。还讨论了在这种情况下丝素蛋白作为支架生物材料的好处和局限性。
重要性陈述
蚕丝蛋白丝素是一种天然生物材料，具有重要的生物和机械特性，可用于软组织工程应用。丝素蛋白是从家蚕中获得的，可以使用基于碱或酶的脱胶（去除胶蛋白丝胶）程序进行纯化。纤维蛋白可单独使用或与其他材料以不同的支架形式结合使用，例如纳米纤维垫、水凝胶、海绵或为特定应用量身定制的薄膜。由于这种独特的生物材料的优势，近年来在皮肤组织工程中使用丝素蛋白或其混合物进行的研究急剧增加。本综述侧重于丝素蛋白在皮肤伤口愈合和/或软组织修复应用中的有前途的特性。
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