Modulation of innate and adaptive immunity by cytomegaloviruses.,Nature Reviews Immunology

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Modulation of innate and adaptive immunity by cytomegaloviruses.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-10-30 , DOI: 10.1038/s41577-019-0225-5
Richard Berry _{1,

2,

3} , Gabrielle M Watson _{1,

2,

3} , Stipan Jonjic ₄ , Mariapia A Degli-Esposti _{1,

5,

6} , Jamie Rossjohn _{1,

2,

3,

7}

Affiliation

The coordinated activities of innate and adaptive immunity are critical for effective protection against viruses. To counter this, some viruses have evolved sophisticated strategies to circumvent immune cell recognition. In particular, cytomegaloviruses encode large arsenals of molecules that seek to subvert T cell and natural killer cell function via a remarkable array of mechanisms. Consequently, these 'immunoevasins' play a fundamental role in shaping the nature of the immune system by driving the evolution of new immune receptors and recognition mechanisms. Here, we review the diverse strategies adopted by cytomegaloviruses to target immune pathways and outline the host's response.

中文翻译：

巨细胞病毒对先天性和适应性免疫的调节。

先天免疫和适应性免疫的协调活动对于有效防御病毒至关重要。为了解决这个问题，一些病毒已经进化出复杂的策略来规避免疫细胞的识别。特别是，巨细胞病毒编码着大量的分子库，这些分子通过一系列显着的机制试图破坏T细胞和自然杀伤细胞的功能。因此，这些“免疫血管素”通过驱动新的免疫受体和识别机制的进化，在塑造免疫系统的本质中起着根本性的作用。在这里，我们回顾了巨细胞病毒针对靶点免疫途径所采取的多种策略，并概述了宿主的反应。

更新日期：2019-10-30

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