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Synthesis and Properties of Polycarbosilanes Having Lactose-Derived Structures
Journal of Polymer Science Part A: Polymer Chemistry Pub Date : 2019-10-30 , DOI: 10.1002/pola.29478 Kozo Matsumoto 1 , Tatsuya Miyano 1 , Yojiro Kotake 1
Journal of Polymer Science Part A: Polymer Chemistry Pub Date : 2019-10-30 , DOI: 10.1002/pola.29478 Kozo Matsumoto 1 , Tatsuya Miyano 1 , Yojiro Kotake 1
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A polycarbosilane having lactose-derived structures was synthesized, and its thermal property, cytotoxicity, chemical crosslinking, and protein adsorption properties were investigated. The polycarbosilane (PSB-Lac) was prepared by a thiol-ene reaction between precursor poly(1-(3-butenyl)-1-methylsilacyclubane) (PSB) and heptaacetyl lactose that carried a thiol group at the anomeric position, and the successive deprotection of the acetyl groups. The lactose introduction efficiency determined by 1H NMR measurement was 75%. TGA and DSC revealed that the polymer had a 5 wt% decomposition temperature of 260 °C and glass transition temperature (Tg) of 84 °C, which indicated that PSB-Lac was a thermally stable polymer. PSB-Lac had no significant cytotoxicity, which was evaluated by human liver cancer cell line HepG2 cultivation on the polystyrene dishes coated with the polymer. Urethane-crosslinked PSB-Lac films were prepared by casting solutions of PSB-Lac and hexamethylene diisocyanate and heating at 120 °C after evaporation of the solvent. The crosslinked PSB-Lac showed higher adsorption of bovine serum albumin than the similarly crosslinked polycarbosilane that had a glucose structure (PSB-Glc). © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2420–2425
中文翻译：
具有乳糖衍生结构的聚碳硅烷的合成与性能
合成了具有乳糖衍生结构的聚碳硅烷，并对其热性能、细胞毒性、化学交联和蛋白质吸附性能进行了研究。聚碳硅烷 (PSB-Lac) 是通过前体聚 (1-(3-丁烯基)-1-甲基硅环丙烷) (PSB) 与在异头位置带有硫醇基团的七乙酰乳糖之间的硫醇-烯反应制备的，然后连续乙酰基的去保护。通过1 H NMR测量确定的乳糖引入效率为75％。TGA 和 DSC 表明该聚合物的 5 wt% 分解温度为 260 °C，玻璃化转变温度 ( T g) 为 84 °C，这表明 PSB-Lac 是一种热稳定聚合物。PSB-Lac 没有显着的细胞毒性，这是通过在涂有聚合物的聚苯乙烯培养皿上培养人肝癌细胞系 HepG2 来评估的。通过浇铸 PSB-Lac 和六亚甲基二异氰酸酯溶液并在溶剂蒸发后在 120°C 加热制备聚氨酯交联的 PSB-Lac 薄膜。交联的 PSB-Lac 比具有葡萄糖结构的类似交联的聚碳硅烷 (PSB-Glc) 显示出更高的牛血清白蛋白吸附。© 2019 Wiley Periodicals, Inc. J. Polym。科学，A 部分：Polym。化学。2019 , 57 , 2420–2425
更新日期：2019-10-30
中文翻译：
具有乳糖衍生结构的聚碳硅烷的合成与性能
合成了具有乳糖衍生结构的聚碳硅烷，并对其热性能、细胞毒性、化学交联和蛋白质吸附性能进行了研究。聚碳硅烷 (PSB-Lac) 是通过前体聚 (1-(3-丁烯基)-1-甲基硅环丙烷) (PSB) 与在异头位置带有硫醇基团的七乙酰乳糖之间的硫醇-烯反应制备的，然后连续乙酰基的去保护。通过1 H NMR测量确定的乳糖引入效率为75％。TGA 和 DSC 表明该聚合物的 5 wt% 分解温度为 260 °C，玻璃化转变温度 ( T g) 为 84 °C，这表明 PSB-Lac 是一种热稳定聚合物。PSB-Lac 没有显着的细胞毒性，这是通过在涂有聚合物的聚苯乙烯培养皿上培养人肝癌细胞系 HepG2 来评估的。通过浇铸 PSB-Lac 和六亚甲基二异氰酸酯溶液并在溶剂蒸发后在 120°C 加热制备聚氨酯交联的 PSB-Lac 薄膜。交联的 PSB-Lac 比具有葡萄糖结构的类似交联的聚碳硅烷 (PSB-Glc) 显示出更高的牛血清白蛋白吸附。© 2019 Wiley Periodicals, Inc. J. Polym。科学，A 部分：Polym。化学。2019 , 57 , 2420–2425
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