Current biochemical understanding regarding the metabolism of acinetobactin, the major siderophore of the human pathogen Acinetobacter baumannii, and outlook for discovery of novel anti-infectious agents based thereon.,Natural Product Reports

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Current biochemical understanding regarding the metabolism of acinetobactin, the major siderophore of the human pathogen Acinetobacter baumannii, and outlook for discovery of novel anti-infectious agents based thereon.
Natural Product Reports ( IF 10.2 ) Pub Date : 2019-10-29 , DOI: 10.1039/c9np00046a
Woon Young Song ₁ , Hak Joong Kim

Affiliation

Covering: 1994 to 2019Owing to the rapid increase in nosocomial infections by antibiotic-resistant Acinetobacter baumannii and the paucity of effective treatment options for such infections, interest in the virulence factors involved in its successful dissemination and propagation in the human host have escalated in recent years. Acinetobacin, a siderophore of A. baumannii, is responsible for iron acquisition under nutritional depravation and has been shown to be one of the key virulence factors for this bacterium. In this Highlight, recent findings regarding various chemical and biological aspects of acinetobactin metabolism closely related to the fitness of A. baumannii at the infection sites have been described. In addition, several notable efforts for identifying novel anti-infectious agents based thereon have been discussed.

中文翻译：

关于不动杆菌素的代谢，人类病原体鲍曼不动杆菌的主要铁载体的当前生化理解，以及基于其的新型抗感染剂的发现前景。

覆盖范围：1994年至2019年由于抗生素耐药性鲍曼不动杆菌的医院内感染迅速增加，并且缺乏有效的治疗选择，近年来，对其在人宿主中成功传播和传播所涉及的毒力因素的兴趣不断上升。不动杆菌，鲍曼不动杆菌的铁载体，在营养减损下负责铁的吸收，并且已被证明是该细菌的关键毒力因子之一。在本集锦中，已描述了有关不动杆菌素代谢的各种化学和生物学方面的最新发现，这些新发现与鲍曼不动杆菌在感染部位的适应性密切相关。另外，已经讨论了用于鉴定基于其的新型抗感染剂的若干显着努力。

更新日期：2019-10-29

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