Stroke recovery treatments that set the field on a radical new path are critically needed.¹ The number of neutral Phase III trials in stroke recovery and rehabilitation suggests that a new approach is required. Recent trials are methodologically rigorous, but often designed with little regard for key, underlying biological mechanisms. The SRRR II Next Trials working group aimed to address the challenge of how we develop the next generation of stroke recovery trials to be both rigorous and aspirational to produce game-changing stroke recovery treatments. The recommendations of this group comprise the current paper.

中文翻译：

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中风恢复试验开发框架：第二次中风恢复和康复圆桌会议基于共识的核心建议

迫切需要中风恢复治疗，以使该领域走上一条崭新的道路。¹中风恢复和康复的中性三期试验的数量表明，需要一种新的方法。最近的试验在方法上很严格，但通常在设计时很少考虑关键的潜在生物学机制。SRRR II Next Trials工作组旨在解决我们如何开发严谨且有抱负的下一代中风恢复试验，以产生改变游戏规则的中风恢复治疗方法的挑战。该小组的建议包括当前的论文。