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Cigarette smoke inhalation aggravates diabetic kidney injury in rats.
Toxicology Research ( IF 2.2 ) Pub Date : 2019-10-29 , DOI: 10.1039/c9tx00201d Songling Jiang 1 , Do Van Quan 2 , Jae Hyuck Sung 3 , Moo-Yeol Lee 2 , Hunjoo Ha 1
Toxicology Research ( IF 2.2 ) Pub Date : 2019-10-29 , DOI: 10.1039/c9tx00201d Songling Jiang 1 , Do Van Quan 2 , Jae Hyuck Sung 3 , Moo-Yeol Lee 2 , Hunjoo Ha 1
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Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. Epidemiological studies have demonstrated that cigarette smoke or nicotine is a risk factor for the progression of chronic kidney injury. The present study analyzed the kidney toxicity of cigarette smoke in experimental rats with DKD. Experimental diabetes was induced in 7-week-old Sprague-Dawley rats by a single intraperitoneal injection of streptozotocin (60 mg kg−1). Four weeks after the induction of diabetes, rats were exposed to cigarette smoke (200 μg L−1), 4 h daily, and 5 days per week for 4 weeks. Cigarette smoke did not affect the levels of plasma glucose, hemoglobin A1c, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol or non-esterified fatty acids in both control and diabetic rats under the experimental conditions. Cigarette smoke, however, significantly increased diabetes-induced glomerular hypertrophy and urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) excretion, suggesting exacerbation of diabetic kidney injury. Cigarette smoke promoted macrophage infiltration and fibrosis in the diabetic kidney. As expected, cigarette smoke increased oxidative stress in both control and diabetic rats. These data demonstrated that four weeks of exposure to cigarette smoke aggravated the progression of DKD in rats.
中文翻译：
吸入香烟烟雾会加剧大鼠的糖尿病肾损伤。
糖尿病肾病（DKD）是终末期肾病的主要原因。流行病学研究表明，香烟烟雾或尼古丁是导致慢性肾脏损伤的危险因素。本研究分析了香烟烟雾对DKD实验大鼠的肾脏毒性。通过单次腹膜内注射链脲佐菌素（60 mg kg -1）在7周大的Sprague-Dawley大鼠中诱发实验性糖尿病。诱发糖尿病四周后，大鼠暴露于香烟烟雾中（200μgL -1），每天4小时和每周5天，共4周。在实验条件下，在对照组和糖尿病大鼠中，香烟烟雾均不影响血浆葡萄糖，血红蛋白A1c，高密度脂蛋白胆固醇，低密度脂蛋白胆固醇或非酯化脂肪酸的水平。但是，香烟烟雾显着增加了糖尿病引起的肾小球肥大和尿肾损伤分子1（KIM-1）和中性粒细胞明胶酶相关的脂蛋白（NGAL）的排泄，提示糖尿病性肾损伤的恶化。香烟烟雾促进了糖尿病肾中巨噬细胞的浸润和纤维化。如预期的那样，香烟烟雾增加了对照组和糖尿病大鼠的氧化应激。这些数据表明，接触香烟烟雾四周加剧了大鼠DKD的进展。
更新日期：2019-10-29
中文翻译：
吸入香烟烟雾会加剧大鼠的糖尿病肾损伤。
糖尿病肾病（DKD）是终末期肾病的主要原因。流行病学研究表明，香烟烟雾或尼古丁是导致慢性肾脏损伤的危险因素。本研究分析了香烟烟雾对DKD实验大鼠的肾脏毒性。通过单次腹膜内注射链脲佐菌素（60 mg kg -1）在7周大的Sprague-Dawley大鼠中诱发实验性糖尿病。诱发糖尿病四周后，大鼠暴露于香烟烟雾中（200μgL -1），每天4小时和每周5天，共4周。在实验条件下，在对照组和糖尿病大鼠中，香烟烟雾均不影响血浆葡萄糖，血红蛋白A1c，高密度脂蛋白胆固醇，低密度脂蛋白胆固醇或非酯化脂肪酸的水平。但是，香烟烟雾显着增加了糖尿病引起的肾小球肥大和尿肾损伤分子1（KIM-1）和中性粒细胞明胶酶相关的脂蛋白（NGAL）的排泄，提示糖尿病性肾损伤的恶化。香烟烟雾促进了糖尿病肾中巨噬细胞的浸润和纤维化。如预期的那样，香烟烟雾增加了对照组和糖尿病大鼠的氧化应激。这些数据表明，接触香烟烟雾四周加剧了大鼠DKD的进展。
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