Construction and Characterization of a Mirror-Image l-DNA i-Motif.,ChemBioChem

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Construction and Characterization of a Mirror-Image l-DNA i-Motif.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-01-03 , DOI: 10.1002/cbic.201900576
Yawei Sun ₁ , Bo Yang ₂ , Yi Hua ₂ , Yuanchen Dong ₃ , Jianhan Ye ₃ , Jiqian Wang ₁ , Lijin Xu ₄ , Dongsheng Liu ₂

Affiliation

The first thermally stable and pH-responsive quadruplex intercalated motif (i-motif) structure formed by l-DNA is presented. Although this l-type i-motif exhibits the same physiochemical properties as its d isomer, its inverted chirality and good enzymatic resistance potentially open the way to the development of new DNA materials of pharmaceutical and biological interest.

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