Juvenile idiopathic arthritis (JIA) is the most common inflammatory arthritis in children; however, an aggressive, erosive arthritis of little‐known immunologic mechanism occurs 20 times more frequently in children with Down syndrome. This study was undertaken to characterize T cell and B cell polyreactivity, follicular helper T (Tfh) cell, peripheral helper T (Tph) cell, and Treg cell responses, and synovial inflammation in Down syndrome–associated arthritis (DA).

中文翻译：

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幼年特发性关节炎和唐氏综合症相关性关节炎儿童的滤泡性辅助因子T，周围性辅助因子T和Treg细胞反应失调可增加T细胞可塑性。

青少年特发性关节炎（JIA）是儿童中最常见的炎症性关节炎；然而，唐氏综合症儿童的免疫机制鲜为人知的侵袭性，侵蚀性关节炎的发生频率是后者的20倍。这项研究的目的是表征唐氏综合症相关关节炎（DA）中的T细胞和B细胞多反应性，滤泡性辅助性T（Tfh）细胞，外周性辅助性T（Tph）细胞和Treg细胞反应以及滑膜炎症。