Dysregulation has been identified as an important risk factor for the development of psychiatric disorders in individuals with autism spectrum disorder (ASD). Therefore, it is necessary to empirically characterize dysregulation and identify psychometrically sound and readily available assessment methods in the ASD population. We sought to evaluate the factor structure of the Child Behavior Checklist‐Dysregulation Profile (CBCL‐DP), an established dysregulation measure in neurotypical children that is derived from the CBCL, in a large, clinically referred sample of children, ages 6–18 years, with ASD (n = 727). Confirmatory factor analysis was used to characterize dysregulation and assess the validity of the CBCL‐DP in children with ASD. Our findings support a bi‐factor model of dysregulation in which dysregulation is a broad and distinct syndrome that is associated with the three subdomains of the CBCL‐DP, anxiety/depression (AD), attention problems (AP), and aggressive behavior (AGG). Dysregulation was associated with most items in the AD and AGG domains and few items in the AP domain. This association with AD and AGG indicates that dysregulation in ASD may be conceptualized as the combined experience of internalized, negative mood states and externalized, reactive behaviors. These findings provide support as well as important caveats for the use of the CBCL‐DP as a measure of dysregulation in the ASD population. Autism Res 2020, 13: 436–443. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.

中文翻译：

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研究自闭症谱系障碍儿童和青少年的儿童行为清单失调特征的因素结构。

失调已被确定为自闭症谱系障碍（ASD）患者发生精神障碍的重要危险因素。因此，有必要从经验上描述失调的特征，并确定ASD人群心理上合理且易于获得的评估方法。我们试图评估儿童行为清单-失调档案（CBCL-DP）的因子结构，这是一种从CBCL衍生出来的神经典型儿童的既定失调措施，来自大量临床参考的6至18岁儿童样本中，带有ASD（n= 727）。验证性因素分析被用来表征失调并评估CBCL-DP在ASD儿童中的有效性。我们的发现支持双因素失调模型，其中失调是一种广泛而独特的综合征，与CBCL-DP的三个子域，焦虑/抑郁（AD），注意问题（AP）和攻击行为（AGG）相关）。失调与AD和AGG域中的大多数项目以及AP域中的少数项目相关。与AD和AGG的这种联系表明，ASD失调可以被概念化为内在的，负面的情绪状态和外在的，反应性行为的综合经验。这些发现为使用CBCL-DP来衡量ASD人群失调提供了支持和重要警告。Autism Res 2020，13：436-443。©2019国际自闭症研究会，Wiley Periodicals，Inc.