Resveratrol Attenuates Pressure Overload-Induced Cardiac Fibrosis and Diastolic Dysfunction via PTEN/AKT/Smad2/3 and NF-κB Signaling Pathways.,Molecular Nutrition & Food Research

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Resveratrol Attenuates Pressure Overload-Induced Cardiac Fibrosis and Diastolic Dysfunction via PTEN/AKT/Smad2/3 and NF-κB Signaling Pathways.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2019-11-08 , DOI: 10.1002/mnfr.201900418
Lei-Xin Zou ₁ , Chen Chen ₁ , Xiao Yan ₁ , Qiu-Yue Lin ₁ , Jiao Fang ₁ , Pang-Bo Li ₂ , Xiao Han ₁ , Qing-Shan Wang ₃ , Shu-Bin Guo ₂ , Hui-Hua Li ₁ , Yun-Long Zhang ₂

Affiliation

Cardiac fibrosis is a key feature of cardiac remodeling. Recently, a protective role for resveratrol (RES) in pressure‐overload‐induced cardiac hypertrophy and contractile dysfunction has been demonstrated. However, the effect of RES on cardiac fibrosis and diastolic function in this model remains unclear.

中文翻译：

白藜芦醇通过PTEN / AKT / Smad2 / 3和NF-κB信号通路减轻压力超负荷引起的心脏纤维化和舒张功能障碍。

心脏纤维化是心脏重塑的关键特征。最近，已证明白藜芦醇（RES）在压力超负荷引起的心脏肥大和收缩功能障碍中具有保护作用。但是，在该模型中，RES对心脏纤维化和舒张功能的影响尚不清楚。

更新日期：2019-11-08

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