The effects of n-butanol on oxidative stress and apoptosis in zebra fish (Danio rerio) larvae.,Comparative Biochemistry and Physiology C: Toxicology & Pharmacology

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The effects of n-butanol on oxidative stress and apoptosis in zebra fish (Danio rerio) larvae.
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2019-10-25 , DOI: 10.1016/j.cbpc.2019.108636
Mine Köktürk ₁ , Gonca Alak ₂ , Muhammed Atamanalp ₂

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In recent years, n-butanol has growing use in many areas, including the food industry. In this study, acute toxic effects of n-butanol to zebrafish (Danio rerio) larvae by applying different concentrations (10, 50, 250, 500, 750, 1000 and 1250 mg/L) to embryos were evaluated. For this purpose the data of oxidative stress, antioxidant - acetyl cholinesterase enzyme activities, malondialdehyde level and apoptosis were taken into consideration. At the end of the 96 h, antioxidant (Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)) and acetylcholinesterase (AChE) enzyme activities were decreased, however lipid peroxidation level, apoptotic cells, and reactive oxygen species increased (p < .05). As a result, it has been observed that high concentrations of n-butanol with its amphiphilic structure causes quite intense toxic effects in zebrafish embryos.

中文翻译：

正丁醇对斑马鱼（Danio rerio）幼虫氧化应激和细胞凋亡的影响。

近年来，正丁醇在包括食品工业在内的许多领域中都有越来越多的用途。在这项研究中，评估了正丁醇对斑马鱼幼虫的急性毒性作用，方法是对胚胎施用不同浓度（10、50、250、500、750、1000和1250 mg / L）的斑马鱼。为此目的，考虑了氧化应激，抗氧化剂-乙酰胆碱酯酶活性，丙二醛水平和细胞凋亡的数据。在96小时结束时，抗氧化剂（超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPx））和乙酰胆碱酯酶（AChE）酶活性降低，但脂质过氧化水平，凋亡细胞和活性氧增加（p <.05）。因此，

更新日期：2019-10-25

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