Fabrication of charged, multiphasic, polymeric micro- and nanoparticles with precise control over their composition, size, and shape is critical for developing the next generation of drug carriers for combinatorial therapies and theranostics. The addition of charged polyelectrolyte multilayers on the surface of polymeric particles can significantly improve their stability, targeting efficacy, drug-release kinetics, and their ability to encapsulate different drugs within a single particle. Many of the traditional methods for multilayer functionalization of multiphasic polymeric particles are time and energy intensive which significantly limits their scalability, and therefore therapeutic potential. In this work, we combine the bulk layer-by-layer polyelectrolyte application methodology with our previously developed technique of fabricating multiphasic polymeric particles on substrates with patterned wettability to synthesize biocompatible, monodisperse, Janus polymer–polyelectrolyte particles.

中文翻译：

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用于制造生物相容性聚合物-聚电解质 Janus 粒子的润湿性模板自组装 (WETS)

制造带电、多相、聚合物微米和纳米粒子并精确控制其组成、大小和形状对于开发用于组合疗​​法和治疗诊断学的下一代药物载体至关重要。在聚合物颗粒表面添加带电聚电解质多层可以显着提高其稳定性、靶向功效、药物释放动力学以及将不同药物封装在单个颗粒中的能力。许多用于多相聚合物颗粒多层官能化的传统方法是时间和能量密集型的，这显着限制了它们的可扩展性，因此也限制了治疗潜力。在这项工作中，