Silicon-containing molecules are of great academic and industrial interest with widespread applications in several research areas such as materials science, medicinal chemistry, and complex-molecule synthesis. C–Si bond formation by direct C–H functionalization is a modern synthetic approach toward highly valuable compounds that offers a superior step and atom economy in contrast to conventional procedures involving at least one prefunctionalized reaction partner. In this review, we summarize the different strategies for C–H silylation. Organized by their reaction mechanism, a representative selection of recent methodologies is introduced and compared with regard to their substrate scope, functional-group tolerance, and regioselectivity.

含硅分子具有重大的学术和工业兴趣，在诸如材料科学，药物化学和复杂分子合成等几个研究领域中得到了广泛的应用。通过直接C–H官能化形成C–Si键是一种现代合成方法，用于制备高价值的化合物，与涉及至少一个预功能化反应伙伴的常规方法相比，该方法具有出色的步骤和原子经济性。在这篇综述中，我们总结了C–H甲硅烷基化的不同策略。通过它们的反应机理进行组织，介绍了一种最新方法的代表性选择，并对其底物范围，功能基团耐受性和区域选择性进行了比较。